Self-assembled lipid bilayer materials
Abstract
The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-CA), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175544
- Patent Number(s):
- 6962747
- Application Number:
- 10/041,846
- Assignee:
- Sandia Corporation
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Sasaki, Darryl Y., Waggoner, Tina A., and Last, Julie A. Self-assembled lipid bilayer materials. United States: N. p., 2005.
Web.
Sasaki, Darryl Y., Waggoner, Tina A., & Last, Julie A. Self-assembled lipid bilayer materials. United States.
Sasaki, Darryl Y., Waggoner, Tina A., and Last, Julie A. Tue .
"Self-assembled lipid bilayer materials". United States. https://www.osti.gov/servlets/purl/1175544.
@article{osti_1175544,
title = {Self-assembled lipid bilayer materials},
author = {Sasaki, Darryl Y. and Waggoner, Tina A. and Last, Julie A.},
abstractNote = {The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {11}
}
Works referenced in this record:
Molecular Architecture and Function of Polymeric Oriented Systems: Models for the Study of Organization, Surface Recognition, and Dynamics of Biomembranes
journal, January 1988
- Ringsdorf, Helmut; Schlarb, Bernhard; Venzmer, Joachim
- Angewandte Chemie International Edition in English, Vol. 27, Issue 1
Hierarchical Self-Assembly of F-Actin and Cationic Lipid Complexes: Stacked Three-Layer Tubule Networks
journal, June 2000
- Wong, G. C. L.
- Science, Vol. 288, Issue 5473
Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes
journal, February 1997
- Radler, J. O.
- Science, Vol. 275, Issue 5301
Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor
journal, May 1995
- Shnek, Deborah R.; Pack, Daniel W.; Arnold, Frances H.
- Angewandte Chemie International Edition in English, Vol. 34, Issue 8
Dithioamide metal ion receptors on fluorescent lipid bilayers for the selective optical detection of mercuric ion
journal, January 1998
- Sasaki, Darryl Y.; Padilla, Benjamin E.
- Chemical Communications, Issue 15
Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers
journal, October 1995
- Ng, Kingman; Pack, Daniel W.; Sasaki, Darryl Y.
- Langmuir, Vol. 11, Issue 10
Optical detection of aqueous phase analytes via host-guest interactions on a lipid membrane surface
conference, June 1999
- Sasaki, Darryl Y.; Waggoner, Tina Y.
- BiOS '99 International Biomedical Optics Symposium, SPIE Proceedings
Higher order self-assembly of vesicles by site-specific binding
journal, June 1994
- Chiruvolu, S.; Walker, S.; Israelachvili, J.
- Science, Vol. 264, Issue 5166
Reversible metal-directed assembly of clusters of vesicles
journal, January 1999
- Constable, Edwin C.; Mundwiler, Stefan; Meier, Wolfgang
- Chemical Communications, Issue 16
Self-Assembled Columns of Stacked Lipid Bilayers Mediated by Metal Ion Recognition
journal, January 2001
- Waggoner, Tina A.; Last, Julie A.; Kotula, Paul G.
- Journal of the American Chemical Society, Vol. 123, Issue 3