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Title: Self-assembled lipid bilayer materials

Abstract

The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175544
Patent Number(s):
6962747
Application Number:
10/041,846
Assignee:
Sandia Corporation
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Sasaki, Darryl Y., Waggoner, Tina A., and Last, Julie A.. Self-assembled lipid bilayer materials. United States: N. p., 2005. Web.
Sasaki, Darryl Y., Waggoner, Tina A., & Last, Julie A.. Self-assembled lipid bilayer materials. United States.
Sasaki, Darryl Y., Waggoner, Tina A., and Last, Julie A.. Tue . "Self-assembled lipid bilayer materials". United States. https://www.osti.gov/servlets/purl/1175544.
@article{osti_1175544,
title = {Self-assembled lipid bilayer materials},
author = {Sasaki, Darryl Y. and Waggoner, Tina A. and Last, Julie A.},
abstractNote = {The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {11}
}

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Works referenced in this record:

Molecular Architecture and Function of Polymeric Oriented Systems: Models for the Study of Organization, Surface Recognition, and Dynamics of Biomembranes
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Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor
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Dithioamide metal ion receptors on fluorescent lipid bilayers for the selective optical detection of mercuric ion
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Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers
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Optical detection of aqueous phase analytes via host-guest interactions on a lipid membrane surface
conference, June 1999


Higher order self-assembly of vesicles by site-specific binding
journal, June 1994


Reversible metal-directed assembly of clusters of vesicles
journal, January 1999


Self-Assembled Columns of Stacked Lipid Bilayers Mediated by Metal Ion Recognition
journal, January 2001