Lipid bilayers on nano-templates

Noy, Aleksandr; Artyukhin, Alexander B; Bakajin, Olgica; Stoeve, Pieter

Title: Lipid bilayers on nano-templates

Abstract

A lipid bilayer on a nano-template comprising a nanotube or nanowire and a lipid bilayer around the nanotube or nanowire. One embodiment provides a method of fabricating a lipid bilayer on a nano-template comprising the steps of providing a nanotube or nanowire and forming a lipid bilayer around the polymer cushion. One embodiment provides a protein pore in the lipid bilayer. In one embodiment the protein pore is sensitive to specific agents

Inventors:

Noy, Aleksandr ^[1]; Artyukhin, Alexander B ^[2]; Bakajin, Olgica ^[3]; Stoeve, Pieter ^[4]

Belmont, CA
Menlo Park, CA
San Leandro, CA
Davis, CA

Issue Date:: 2009-08-04

Research Org.:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1013872

Patent Number(s):: 7569850

Application Number:: 11/338,513

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K9/0092 - {Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules, nanotubes

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/702 - having biological material component
Y10S977/907 - Liposome

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Show less

DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats


                    Noy, Aleksandr, Artyukhin, Alexander B, Bakajin, Olgica, and Stoeve, Pieter. Lipid bilayers on nano-templates.  United States: N. p., 2009. 
        Web.

Copy to clipboard


                    Noy, Aleksandr, Artyukhin, Alexander B, Bakajin, Olgica, & Stoeve, Pieter. Lipid bilayers on nano-templates.  United States.

Copy to clipboard


                    Noy, Aleksandr, Artyukhin, Alexander B, Bakajin, Olgica, and Stoeve, Pieter. Tue .  
        "Lipid bilayers on nano-templates".  United States.  https://www.osti.gov/servlets/purl/1013872.

Copy to clipboard


                    
@article{osti_1013872,

  title        = {Lipid bilayers on nano-templates},

  author       = {Noy, Aleksandr and Artyukhin, Alexander B and Bakajin, Olgica and Stoeve, Pieter},

  abstractNote = {A lipid bilayer on a nano-template comprising a nanotube or nanowire and a lipid bilayer around the nanotube or nanowire. One embodiment provides a method of fabricating a lipid bilayer on a nano-template comprising the steps of providing a nanotube or nanowire and forming a lipid bilayer around the polymer cushion. One embodiment provides a protein pore in the lipid bilayer. In one embodiment the protein pore is sensitive to specific agents},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2009},

  month        = {8}

}

Copy to clipboard

Patent:

View Patent

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates
journal, May 2005

Artyukhin, Alexander B.; Shestakov, Aleksei; Harper, Jennifer
Journal of the American Chemical Society, Vol. 127, Issue 20
https://doi.org/10.1021/ja043431g

Biomolecule-Functionalized Carbon Nanotubes: Applications in Nanobioelectronics
journal, August 2004

Katz, Eugenii; Willner, Itamar
ChemPhysChem, Vol. 5, Issue 8
https://doi.org/10.1002/cphc.200400193

Similar Records in DOE Patents and OSTI.GOV collections:

Self-assembled lipid bilayer materials

Patent Sasaki, Darryl Y.; Waggoner, Tina A.; Last, Julie A.

The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.
Full Text Available
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

Patent Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin; ...

The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleusmore »« less
Full Text Available
Immobilized lipid-bilayer materials

Patent Sasaki, Darryl Y [Albuquerque, NM]; Loy, Douglas A [Albuquerque, NM]; Yamanaka, Stacey A [Dallas, TX]

A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.
Full Text Available
Compositions including nano-particles and a nano-structured support matrix and methods of preparation as reversible high capacity anodes in energy storage systems

Patent Kumta, Prashant Nagesh; Wang, Wei; Jampani Hanumantha, Prashanth; ...

The present invention relates to compositions including nano-particles and a nano-structured support matrix, methods of their preparation and applications thereof. The compositions of the present invention are particularly suitable for use as anode material for lithium-ion rechargeable batteries. The nano-structured support matrix can include nanotubes, nanowires, nanorods, and mixtures thereof. The composition can further include a substrate on which the nano-structured support matrix is formed. The substrate can include a current collector material.
Full Text Available
Nano-fabricated superconducting radio-frequency composites, method for producing nano-fabricated superconducting rf composites

Patent Norem, James H.; Pellin, Michael J.

Superconducting rf is limited by a wide range of failure mechanisms inherent in the typical manufacture methods. This invention provides a method for fabricating superconducting rf structures comprising coating the structures with single atomic-layer thick films of alternating chemical composition. Also provided is a cavity defining the invented laminate structure.
Full Text Available

Similar Records

Title: Lipid bilayers on nano-templates

Abstract

Citation Formats

Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates journal, May 2005

Biomolecule-Functionalized Carbon Nanotubes: Applications in Nanobioelectronics journal, August 2004

Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates
journal, May 2005

Biomolecule-Functionalized Carbon Nanotubes: Applications in Nanobioelectronics
journal, August 2004