Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
Abstract
A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 872119
- Patent Number(s):
- 5864397
- Assignee:
- Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-96OR22464
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- surface-enhanced; raman; medical; probes; disease; diagnosis; drug; testing; probe; scattering; spectrometer; optically; transmissive; material; receiving; excitation; radiation; laser; carrying; emitted; specimen; detector; placing; coating; produces; surface; enhancement; spectroscopic; analysis; specifically; formed; layer; microparticles; metal; form; microstructure; applied; alternatively; containing; optional; concentrate; compounds; analytical; excitation radiation; surface-enhanced raman; spectroscopic analysis; raman scattering; metal layer; material containing; radiation emitted; enhanced raman; scattering spectrometer; transmissive material; /356/
Citation Formats
Vo-Dinh, Tuan. Surface-enhanced raman medical probes and system for disease diagnosis and drug testing. United States: N. p., 1999.
Web.
Vo-Dinh, Tuan. Surface-enhanced raman medical probes and system for disease diagnosis and drug testing. United States.
Vo-Dinh, Tuan. Fri .
"Surface-enhanced raman medical probes and system for disease diagnosis and drug testing". United States. https://www.osti.gov/servlets/purl/872119.
@article{osti_872119,
title = {Surface-enhanced raman medical probes and system for disease diagnosis and drug testing},
author = {Vo-Dinh, Tuan},
abstractNote = {A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}