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Title: Surface-enhanced raman medical probes and system for disease diagnosis and drug testing

Abstract

A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.

Inventors:
 [1]
  1. (Knoxville, TN)
Issue Date:
Research Org.:
LOCKHEED MARTIN ENERGY RES COR
OSTI Identifier:
872119
Patent Number(s):
5864397
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
surface-enhanced; raman; medical; probes; disease; diagnosis; drug; testing; probe; scattering; spectrometer; optically; transmissive; material; receiving; excitation; radiation; laser; carrying; emitted; specimen; detector; placing; coating; produces; surface; enhancement; spectroscopic; analysis; specifically; formed; layer; microparticles; metal; form; microstructure; applied; alternatively; containing; optional; concentrate; compounds; analytical; excitation radiation; surface-enhanced raman; spectroscopic analysis; raman scattering; metal layer; material containing; radiation emitted; enhanced raman; scattering spectrometer; transmissive material; /356/

Citation Formats

Vo-Dinh, Tuan. Surface-enhanced raman medical probes and system for disease diagnosis and drug testing. United States: N. p., 1999. Web.
Vo-Dinh, Tuan. Surface-enhanced raman medical probes and system for disease diagnosis and drug testing. United States.
Vo-Dinh, Tuan. Fri . "Surface-enhanced raman medical probes and system for disease diagnosis and drug testing". United States. https://www.osti.gov/servlets/purl/872119.
@article{osti_872119,
title = {Surface-enhanced raman medical probes and system for disease diagnosis and drug testing},
author = {Vo-Dinh, Tuan},
abstractNote = {A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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