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Title: Surface-enhanced Raman medical probes and system for disease diagnosis and drug testing

Abstract

A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe. 39 figs.

Inventors:
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
321269
Patent Number(s):
5864397
Application Number:
PAN: 8-929,612
Assignee:
Lockheed Martin Energy Research Corp., Oak Ridge, TN (United States)
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 26 Jan 1999
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RAMAN SPECTRA; PROBES; DIAGNOSIS; DISEASES; MEDICINE; SPECTROMETERS; DESIGN; DRUGS

Citation Formats

Vo-Dinh, T. Surface-enhanced Raman medical probes and system for disease diagnosis and drug testing. United States: N. p., 1999. Web.
Vo-Dinh, T. Surface-enhanced Raman medical probes and system for disease diagnosis and drug testing. United States.
Vo-Dinh, T. Tue . "Surface-enhanced Raman medical probes and system for disease diagnosis and drug testing". United States.
@article{osti_321269,
title = {Surface-enhanced Raman medical probes and system for disease diagnosis and drug testing},
author = {Vo-Dinh, T},
abstractNote = {A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe. 39 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}