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Title: Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates

The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest.
Inventors:
 [1];  [2]
  1. (Whitestone, NY)
  2. (New York, NY)
Issue Date:
OSTI Identifier:
871059
Assignee:
Trustees of Columbia University in City of New York (New York, NY) CHO
Patent Number(s):
US 5650284
Contract Number:
FG02-88ER60742
Research Org:
University of Vermont
Country of Publication:
United States
Language:
English
Subject:
enhancing; sensitivity; immunoassay; procedures; antibodies; directed; product; reaction; probe; labels; assay; substrates; subject; provides; antibody; specifically; binds; labeling; substance; substrate; method; immunogen; produce; methods; detecting; antigen; sample; example; protein; comprising; amino; acid; sequence; nucleic; molecule; acid molecule; provides methods; acid sequence; amino acid; nucleic acid; specifically bind; molecule comprising; specifically binds; immunoassay procedures; probe labels; antibodies directed; assay substrates; /435/530/