Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

Schaff, Ulrich Y; Koh, Chung-Yan; Sommer, Gregory J

Title: Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

Abstract

Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.

Inventors:: Schaff, Ulrich Y; Koh, Chung-Yan; Sommer, Gregory J

Issue Date:: 2015-02-24

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1171088

Patent Number(s):: 8962346

Application Number:: 13/423,050

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2200/0668 - Trapping microscopic beads
B01L2200/0673 - Handling of plugs of fluid surrounded by immiscible fluid
B01L2400/0409 - centrifugal forces
B01L3/50215 - {using a float to separate phases}
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N15/04 - Investigating sedimentation of particle suspensions
G01N21/6428 - {Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
G01N33/54313 - {the carrier being characterised by its particulate form}
G01N33/558 - using diffusion or migration of antigen or antibody

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Mar 16

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

Citation Formats


                    Schaff, Ulrich Y, Koh, Chung-Yan, and Sommer, Gregory J. Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation.  United States: N. p., 2015. 
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                    Schaff, Ulrich Y, Koh, Chung-Yan, & Sommer, Gregory J. Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation.  United States.

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                    Schaff, Ulrich Y, Koh, Chung-Yan, and Sommer, Gregory J. Tue .  
        "Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation".  United States.  https://www.osti.gov/servlets/purl/1171088.

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@article{osti_1171088,

  title        = {Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation},

  author       = {Schaff, Ulrich Y and Koh, Chung-Yan and Sommer, Gregory J},

  abstractNote = {Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {2}

}

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Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

Patent Schaff, Ulrich Y.; Koh, Chung-Yan; Sommer, Gregory J.

Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with amore » « less
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Devices, systems, and methods for conducting sandwich assays using sedimentation

Patent Schaff, Ulrich Y; Sommer, Gregory J; Singh, Anup K; ...

Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signalmore » « less
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Systems, devices, and methods for agglutination assays using sedimentation

Patent Schaff, Ulrich Y.; Sommer, Gregory Jon; Singh, Anup K.

Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.
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Systems, devices, and methods for agglutination assays using sedimentation

Patent Schaff, Ulrich Y.; Sommer, Gregory J.; Singh, Anup K.

Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.
Full Text Available
Devices, systems, and methods for detecting nucleic acids using sedimentation

Patent Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory J.

Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transportingmore » « less
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Title: Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

Abstract

Citation Formats

Axial Bearing patent, March 1966

Multistation, Single Channel Analytical Photometer and Method of Use patent, January 1971

Loading Disk for Photometric Analyzer of Rotary Cuvette Type patent, July 1973

Rotatable Finned Heat Transfer Device patent, October 1974

Separation of solid and liquid components of mixtures patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood patent, May 1979

Compact miniature fan patent, August 1979

Reversible drive circuit for brushless DC motor patent, August 1981

Gas-lubricated bearings patent, April 1983

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent, November 1985

Heterogeneous binding assay patent, April 1987

Method and apparatus for measuring blood constituent counts patent, July 1987

Method for separating the cellular components of blood samples patent, July 1989

Dynamic heat sink patent, March 1991

Thermal control variable speed DC brushless fan patent, March 1993

Method of separation employing magnetic particles and second medium patent, January 1994

Cooling microfan arrangements and process patent, March 1994

Heat exchange apparatus and method for preparing the apparatus patent, March 1994

Disk augmented heat transfer system patent, August 1994

Heat sink assembly for a central processing unit of a computer patent, December 1996

Fan motor patent, April 1997

Assay of blood or other biologic samples for target analytes patent, June 1997

DNA purification and isolation using magnetic particles patent, January 1998

Fan speed monitoring system for determining the speed of a PWM fan patent, March 1998

Transistor package structured to provide heat dissipation enabling use of silicon carbide transistors and other high power semiconductor devices patent, April 1998

Forced air cooling apparatus for semiconductor chips patent, August 1998

Assay system and method for conducting assays patent, March 1999

Heat sink apparatus patent, September 1999

Apparatus for optimizing the rotational speed of cooling fans patent, October 1999

Cooling fan and cooling fan assembly patent, November 1999

Method and apparatus for cooling an electronic device patent, April 2000

Data storage and/or retrieval methods and apparatuses and components thereof patent, June 2000

Centrifugal hematology disposable patent, November 2000

Heat transfer apparatus patent, January 2001

Fan with magnetic blades patent, February 2001

Rotor drive motor with u-shaped stator cores patent, June 2001

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

CPU fan assembly patent, March 2002

Microfluidic systems patent, April 2002

Substrate structure of a liquid crystal display and a manufacturing method thereof patent, May 2002

Composite heat dissipation fan patent, October 2002

Circuit board fixing structure of heatsink fan patent, February 2003

Cooling module and related control circuits useful therefor incorporating a communication port for receiving digital command signals to control module patent, April 2003

Cooling apparatus for cooling electric element patent, September 2003

Multilevel flow structures patent, September 2003

Method and device for separation of charged molecules by solution isoelectric focusing patent, October 2003

Cooler for electronic devices patent, December 2003

Cooler for electronic devices patent, December 2003

Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels patent, February 2004

Radiator fan patent, March 2005

Very thin fan motor with attached heat sink patent, March 2005

Active heat sink for high power microprocessors patent, April 2005

Speed control circuit of brushless DC fan motor patent, April 2005

Monolithic microfluidic concentrators and mixers patent, May 2005

Hybrid cooling system and method for cooling electronic devices patent, October 2005

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent, November 2005

Venturi fan patent, November 2005

Apparatus for cooling of electronic components patent, April 2006

Multi-parameter assays including analysis discs and methods relating thereto patent, April 2006

Apparatus for air cooling of an electronic device patent, April 2006

Cooler for electronic devices patent, May 2006

Impeller driven active heat sink patent, June 2006

Photomagnetic field sensor patent, July 2006

Integrated liquid cooling system for electrical components patent, September 2006

Radial-flow heat-dissipating fan with increased inlet airflow patent, November 2006

Wave-fans and wave-fans with heat sinks patent, November 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent, January 2007

Integrated liquid cooling device with immersed electronic components patent, January 2007

Fan device for removing heat from heat sources patent, January 2007

CPU heat dissipating device structure patent, September 2007

Heat-dissipating device patent, September 2007

Cooling apparatus for heat generating devices patent, September 2007

Heatsink assembly and method of manufacturing the same patent, October 2007

Heat-receiving apparatus and electronic equipment patent, November 2007

Heat sink assembly patent, December 2007

Microfluidic particle-analysis systems patent, December 2007

Dual impeller push-pull axial fan heat sink patent, January 2008

Axial Bearing
patent, March 1966

Multistation, Single Channel Analytical Photometer and Method of Use
patent, January 1971

Loading Disk for Photometric Analyzer of Rotary Cuvette Type
patent, July 1973

Rotatable Finned Heat Transfer Device
patent, October 1974

Separation of solid and liquid components of mixtures
patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood
patent, May 1979

Compact miniature fan
patent, August 1979

Reversible drive circuit for brushless DC motor
patent, August 1981

Gas-lubricated bearings
patent, April 1983

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device
patent, November 1985

Heterogeneous binding assay
patent, April 1987

Method and apparatus for measuring blood constituent counts
patent, July 1987

Method for separating the cellular components of blood samples
patent, July 1989

Dynamic heat sink
patent, March 1991

Thermal control variable speed DC brushless fan
patent, March 1993

Method of separation employing magnetic particles and second medium
patent, January 1994

Cooling microfan arrangements and process
patent, March 1994

Heat exchange apparatus and method for preparing the apparatus
patent, March 1994

Disk augmented heat transfer system
patent, August 1994

Heat sink assembly for a central processing unit of a computer
patent, December 1996

Fan motor
patent, April 1997

Assay of blood or other biologic samples for target analytes
patent, June 1997

DNA purification and isolation using magnetic particles
patent, January 1998

Fan speed monitoring system for determining the speed of a PWM fan
patent, March 1998

Transistor package structured to provide heat dissipation enabling use of silicon carbide transistors and other high power semiconductor devices
patent, April 1998

Forced air cooling apparatus for semiconductor chips
patent, August 1998

Assay system and method for conducting assays
patent, March 1999

Heat sink apparatus
patent, September 1999

Apparatus for optimizing the rotational speed of cooling fans
patent, October 1999

Cooling fan and cooling fan assembly
patent, November 1999

Method and apparatus for cooling an electronic device
patent, April 2000

Data storage and/or retrieval methods and apparatuses and components thereof
patent, June 2000

Centrifugal hematology disposable
patent, November 2000

Heat transfer apparatus
patent, January 2001

Fan with magnetic blades
patent, February 2001

Rotor drive motor with u-shaped stator cores
patent, June 2001

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent, November 2001

CPU fan assembly
patent, March 2002

Microfluidic systems
patent, April 2002

Substrate structure of a liquid crystal display and a manufacturing method thereof
patent, May 2002

Composite heat dissipation fan
patent, October 2002

Circuit board fixing structure of heatsink fan
patent, February 2003

Cooling module and related control circuits useful therefor incorporating a communication port for receiving digital command signals to control module
patent, April 2003

Cooling apparatus for cooling electric element
patent, September 2003

Multilevel flow structures
patent, September 2003

Method and device for separation of charged molecules by solution isoelectric focusing
patent, October 2003

Cooler for electronic devices
patent, December 2003

Cooler for electronic devices
patent, December 2003

Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
patent, February 2004

Radiator fan
patent, March 2005

Very thin fan motor with attached heat sink
patent, March 2005

Active heat sink for high power microprocessors
patent, April 2005

Speed control circuit of brushless DC fan motor
patent, April 2005

Monolithic microfluidic concentrators and mixers
patent, May 2005

Hybrid cooling system and method for cooling electronic devices
patent, October 2005

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent, November 2005

Venturi fan
patent, November 2005

Apparatus for cooling of electronic components
patent, April 2006

Multi-parameter assays including analysis discs and methods relating thereto
patent, April 2006

Apparatus for air cooling of an electronic device
patent, April 2006

Cooler for electronic devices
patent, May 2006

Impeller driven active heat sink
patent, June 2006

Photomagnetic field sensor
patent, July 2006

Integrated liquid cooling system for electrical components
patent, September 2006

Radial-flow heat-dissipating fan with increased inlet airflow
patent, November 2006

Wave-fans and wave-fans with heat sinks
patent, November 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
patent, January 2007

Integrated liquid cooling device with immersed electronic components
patent, January 2007

Fan device for removing heat from heat sources
patent, January 2007

CPU heat dissipating device structure
patent, September 2007

Heat-dissipating device
patent, September 2007

Cooling apparatus for heat generating devices
patent, September 2007

Heatsink assembly and method of manufacturing the same
patent, October 2007

Heat-receiving apparatus and electronic equipment
patent, November 2007

Heat sink assembly
patent, December 2007

Microfluidic particle-analysis systems
patent, December 2007

Dual impeller push-pull axial fan heat sink
patent, January 2008

Heat dissipation device
patent, March 2008

Fan motor
patent, June 2008

Miniature blower fan
patent, November 2008