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Title: Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates

Abstract

The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites. 25 figs.

Inventors:
;
Issue Date:
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
6376251
Patent Number(s):
5925532 A
Application Number:
PPN: US 8-898583
Assignee:
Columbia Univ., New York, NY (United States) PTO; EDB-99-086043
DOE Contract Number:  
FG02-88ER60742
Resource Type:
Patent
Resource Relation:
Patent File Date: 22 Jul 1997
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BIOCHEMICAL REACTION KINETICS; IMMUNOASSAY; NUCLEIC ACIDS; PROTEINS; SPECIFICITY; SUBSTRATES; BIOASSAY; KINETICS; ORGANIC COMPOUNDS; REACTION KINETICS; 550200* - Biochemistry

Citation Formats

Erlanger, B.F., and Chen, B. Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates. United States: N. p., 1999. Web.
Erlanger, B.F., & Chen, B. Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates. United States.
Erlanger, B.F., and Chen, B. Tue . "Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates". United States.
@article{osti_6376251,
title = {Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates},
author = {Erlanger, B.F. and Chen, B.},
abstractNote = {The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites. 25 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {7}
}