Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
Antibodies against stage specific embryonic antigen-1 is radiolabeled by direct means with a radionuclide for use in detection of occult abscess and inflammation. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the antibody using Sn(II), or using other reducing agents followed by the addition of Sn(II), removal of excess reducing agent and reduction by-products, and addition of a specified amount of radionuclide reducing agent, such as stannous tartrate. The resulting product may be stored frozen or lyophilized, with radiolabeling accomplished by the addition of the radionuclide. No Drawings
- Issue Date:
- OSTI Identifier:
- 6925998
- Assignee:
- Rhomed Inc., Albuquerque, NM (United States) PTO; EDB-94-155141
- Patent Number(s):
- US 5346687; A
- Application Number:
- PPN: US 7-816476
- Contract Number:
- FG04-89ER60899
- Resource Relation:
- Patent File Date: 3 Jan 1992
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; LABELLING; ANTIGEN-ANTIBODY REACTIONS; DIAGNOSTIC USES; IMAGE PROCESSING; PROCESSING; USES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics