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Title: Method to directly radiolabel antibodies for diagnostic imaging and therapy

The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.
Inventors:
 [1]
  1. (Cherry Hill, NJ)
Issue Date:
OSTI Identifier:
869275
Assignee:
Thomas Jefferson University (Philadelphia, PA) SNL
Patent Number(s):
US 5308603
Contract Number:
AC04-76
Research Org:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA
Country of Publication:
United States
Language:
English
Subject:
method; directly; radiolabel; antibodies; diagnostic; imaging; therapy; novel; kit; radiolabeling; proteins; antibody; fragments; therapeutic; purposes; comprises; incubating; protein-containing; solution; sodium; ascorbate; adding; required; quantity; reduced; radionuclide; incubated; protein; provided; reducing; agents; lyophilized; form; reducing agents; therapeutic purposes; method comprises; reducing agent; novel method; antibody fragment; method comprise; diagnostic imaging; radiolabel antibodies; radiolabeling proteins; containing solution; reduced radio; antibody fragments; directly radiolabeling; directly radiolabel; /424/530/