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Title: Method to directly radiolabel antibodies for diagnostic imaging and therapy

Abstract

The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.

Inventors:
 [1]
  1. Cherry Hill, NJ
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA
OSTI Identifier:
867794
Patent Number(s):
5011676
Assignee:
Thomas Jefferson University (Philadelphia, PA)
DOE Contract Number:  
AC04-76
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; directly; radiolabel; antibodies; diagnostic; imaging; therapy; novel; kit; radiolabeling; proteins; antibody; fragments; therapeutic; purposes; comprises; incubating; protein-containing; solution; sodium; ascorbate; adding; required; quantity; reduced; radionuclide; incubated; protein; provided; reducing; agents; lyophilized; form; reducing agents; therapeutic purposes; method comprises; reducing agent; novel method; antibody fragment; method comprise; diagnostic imaging; radiolabel antibodies; radiolabeling proteins; containing solution; reduced radio; antibody fragments; directly radiolabeling; directly radiolabel; /530/

Citation Formats

Thakur, Mathew L. Method to directly radiolabel antibodies for diagnostic imaging and therapy. United States: N. p., 1991. Web.
Thakur, Mathew L. Method to directly radiolabel antibodies for diagnostic imaging and therapy. United States.
Thakur, Mathew L. Tue . "Method to directly radiolabel antibodies for diagnostic imaging and therapy". United States. https://www.osti.gov/servlets/purl/867794.
@article{osti_867794,
title = {Method to directly radiolabel antibodies for diagnostic imaging and therapy},
author = {Thakur, Mathew L},
abstractNote = {The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {1}
}

Patent:

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