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Title: Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging

Abstract

Antibody against stage specific embryonic antigen-1 is radiolabeled by direct means with a radionuclide for use in detection of occult abscess and inflammation. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the antibody using Sn(II), or using other reducing agents followed by the addition of Sn(II), removal of excess reducing agent and reduction by-products, and addition of a specified amount of radionuclide reducing agent, such as stannous tartrate. The resulting product may be store frozen or lyophilized, with radiolabeling accomplished by the addition of the radionuclide.

Inventors:
 [1]
  1. (Albuquerque, NM)
Issue Date:
Research Org.:
RhoMed, Inc., Albuquerque, NM
OSTI Identifier:
869490
Patent Number(s):
5346687
Assignee:
Rhomed Incorporated (Albuquerque, NM) ALO
DOE Contract Number:  
FG04-89ER60899
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
direct; radiolabeling; antibody; stage; specific; embryonic; antigen; diagnostic; imaging; antigen-1; radiolabeled; means; radionuclide; detection; occult; abscess; inflammation; accomplished; partial; reduction; disulfide; bonds; ii; reducing; agents; followed; addition; removal; excess; agent; by-products; specified; amount; stannous; tartrate; resulting; product; store; frozen; lyophilized; reducing agents; resulting product; reducing agent; specific embryonic; stage specific; diagnostic imaging; occult abscess; embryonic antigen-1; embryonic antigen; agents followed; /424/530/

Citation Formats

Rhodes, Buck A. Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging. United States: N. p., 1994. Web.
Rhodes, Buck A. Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging. United States.
Rhodes, Buck A. Sat . "Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging". United States. https://www.osti.gov/servlets/purl/869490.
@article{osti_869490,
title = {Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging},
author = {Rhodes, Buck A.},
abstractNote = {Antibody against stage specific embryonic antigen-1 is radiolabeled by direct means with a radionuclide for use in detection of occult abscess and inflammation. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the antibody using Sn(II), or using other reducing agents followed by the addition of Sn(II), removal of excess reducing agent and reduction by-products, and addition of a specified amount of radionuclide reducing agent, such as stannous tartrate. The resulting product may be store frozen or lyophilized, with radiolabeling accomplished by the addition of the radionuclide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

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