Methods of producing lipid-derived compounds and host cells thereof
Abstract
The present disclosure relates to genetically engineered host cells and methods of producing a lipid-derived compound by employing such host cells. In particular embodiments, the host cell includes a first mutant gene encoding a cytoplasmic tRNA thiolation protein. Optionally, the host cell can include other mutant genes for decreasing fatty alcohol catabolism, decreasing re-importation of secreted fatty alcohol, or displaying other useful characteristics, as described herein.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-CA), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1987064
- Patent Number(s):
- 11560576
- Application Number:
- 17/323,195
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
- DOE Contract Number:
- NA0003525
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/18/2021
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Coradetti, Samuel, Gladden, John Michael, Liu, Di, and Geiselman, Gina Marie. Methods of producing lipid-derived compounds and host cells thereof. United States: N. p., 2023.
Web.
Coradetti, Samuel, Gladden, John Michael, Liu, Di, & Geiselman, Gina Marie. Methods of producing lipid-derived compounds and host cells thereof. United States.
Coradetti, Samuel, Gladden, John Michael, Liu, Di, and Geiselman, Gina Marie. Tue .
"Methods of producing lipid-derived compounds and host cells thereof". United States. https://www.osti.gov/servlets/purl/1987064.
@article{osti_1987064,
title = {Methods of producing lipid-derived compounds and host cells thereof},
author = {Coradetti, Samuel and Gladden, John Michael and Liu, Di and Geiselman, Gina Marie},
abstractNote = {The present disclosure relates to genetically engineered host cells and methods of producing a lipid-derived compound by employing such host cells. In particular embodiments, the host cell includes a first mutant gene encoding a cytoplasmic tRNA thiolation protein. Optionally, the host cell can include other mutant genes for decreasing fatty alcohol catabolism, decreasing re-importation of secreted fatty alcohol, or displaying other useful characteristics, as described herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 24 00:00:00 EST 2023},
month = {Tue Jan 24 00:00:00 EST 2023}
}
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