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Title: Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound

The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1260248
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,382,553
Application Number:
13/587,826
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2012 Aug 16
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Other works cited in this record:

Biosynthesis of isoprenoids via the non-mevalonate pathway
journal, June 2004
  • Eisenreich, W.; Bacher, A.; Arigoni, D.
  • Cellular and Molecular Life Sciences, Vol. 61, Issue 12, p. 1401-1426
  • DOI: 10.1007/s00018-004-3381-z

Computational Analysis of the Evolution of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase, an Important Enzyme in Plant Terpene Biosynthesis
journal, May 2010
  • Fung, Pui Kwan; Krushkal, Julia; Weathers, Pamela J.
  • Chemistry & Biodiversity, Vol. 7, Issue 5, p. 1098-1110
  • DOI: 10.1002/cbdv.200900313

Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli:
journal, January 2001

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