Host cells and methods for producing diacid compounds
Abstract
The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1436519
- Patent Number(s):
- 9951345
- Application Number:
- 13/900,397
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 May 22
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., and Keasling, Jay D.. Host cells and methods for producing diacid compounds. United States: N. p., 2018.
Web.
Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., & Keasling, Jay D.. Host cells and methods for producing diacid compounds. United States.
Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., and Keasling, Jay D.. Tue .
"Host cells and methods for producing diacid compounds". United States. https://www.osti.gov/servlets/purl/1436519.
@article{osti_1436519,
title = {Host cells and methods for producing diacid compounds},
author = {Steen, Eric J. and Fortman, Jeffrey L. and Dietrich, Jeffrey A. and Keasling, Jay D.},
abstractNote = {The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}
}
Works referenced in this record:
Site-specific modification of the candida tropicals genome
patent, October 1993
- Picataggio, Stephen; Deanda, Kristine A.; Eirich, L. Dudley
- US Patent Document 5,254,466
Method for increasing the omega-hydroxylase activity in Candida tropicalis
patent, April 1997
- Picataggio, Stephen; Rohrer, Tracy; Eirich, L. Dudley
- US Patent Document 5,620,878
Method for increasing the omega-hydroxylase activity in candida tropicals
patent, July 1997
- Picataggio, Stephen; Rohrer, Tracy; Eirich, L. Dudley
- US Patent Document 5,648,247
Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids
patent, May 2000
- Mobley, David Paul; Shank, Gary
- US Patent Document 6,066,480
Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto
patent, January 2003
- Craft, David L.; Madduri, Krishna M.; Loper, John C.
- US Patent Document 6,503,734
Method of increasing conversion of a fatty acid to its corresponding dicarboxylic acid
patent, September 2004
- Craft, David L.; Wilson, C. Ron; Eirich, Dudley
- US Patent Document 6,790,640
Cytochrome P450 monooxygenase CYP52A2B from Candida tropicalis
patent, May 2006
- Wilson, C. Ron; Craft, David L.; Eirich, L. Dudley
- US Patent Document 7,049,112
Fatty alcohol oxidase genes and proteins from Candida tropicalis and methods relating thereto
patent, January 2007
- Eirich, L. Dudley; Craft, David L.
- US Patent Document 7,160,708
Cytochrome P450 oxygenases
patent, June 2007
- Farinas, Edgardo T.; Arnold, Frances H.; Schwaneberg, Ulrich
- US Patent Document 7,226,768
Biooxidation capabilities of Candida sp
patent, July 2008
- Eirich, L. Dudley; Anderson, Kevin W.; Gates, Jeffrey A.
- US Patent Document 7,405,063
Process for preparing long-chain dicarboxylic acids
patent, February 2013
- Kamal, Ahmed; Gurrala, Sheelu; Fadnavis, Wasantrao Nitin
- US Patent Document 8,383,373
Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto
patent-application, August 2003
- Wilson, C. Ron; Craft, David L.; Dudley, Eirich L.
- US Patent Application 10/139218; 20030153060
Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates
patent-application, July 2004
- Fallon, Robert D.; Payne, Mark S.; Picataggio, Stephen K.
- US Patent Application 10/792560; 20040146999
Use of POX4 promoter to increase gene expression in Candida tropicalis
patent-application, December 2004
- Zhang, Yeyan; Wilson, C. Ron; Craft, David L.
- US Patent Application 10/629266; 20040265980
Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use
patent-application, October 2009
- Arnold, Frances H.; Cirino, Patrick C.
- US Patent Application 12/287707; 20090264311
Secretion of Fatty Acids by Photosynthetic Microorganisms
patent-application, December 2009
- Roessler, Paul Gordon; Chen, You; Liu, Bo
- US Patent Application 12/333280; 20090298143
Methods and Compositions Related to Thioesterase Enzymes
patent-application, June 2010
- Hom, Louis; Trinh, Na; Ahbhai, Murtaza
- US Patent Application 12/645497; 20100154293
Methods for the Synthesis of Fatty Diacids by the Metathesis of Unsaturated Diacids Obtained by Fermentation of Natural Fatty Acids
patent-application, August 2010
- Dubois, Jean-Luc
- US Patent Application 12/678366; 20100196973
Biosynthetic Routes to Long-Chain Alpha, Omega-Hydroxyacids, Diacids and Their Conversion to Oligomers and Polymers
patent-application, November 2010
- Gross, Richard A.; Lu, Wenhua; Ness, Jon
- US Patent Application 12/436729; 20100285545
Biotransformation Using Genetically Modified Candida
patent-application, November 2010
- Ness, Jon E.; Minshull, Jeremy
- US Patent Application 12/775306; 20100291653
Omega-Amino Carboxylic Acids, Omega-Amino Carboxylic Acid Eaters, or Recombinant Cells which Produce Lactams Thereof
patent-application, December 2010
- Karan, Andreas; Sieber, Volker; Haas, Thomas
- US Patent Application 12/742318; 20100324257
Fatty Acid-Producing Hosts
patent, July 2011
- Pfleger, Brian F.; Lennen, Rebecca M.
- US Patent Document 12/984343; 20110165637
Biological Methods for Preparing Adipic Acid
patent-application, March 2012
- Picataggio, Stephen; Beardslee, Tom
- US Patent Application 13/245782; 20120077237
Industrial Fatty Acid Engineering General System for Modifying Fatty Acids
patent-application, April 2013
- Kurek, Itzhak; Siani-Rose, Michael; Dyson, Iisa
- US Patent Application 13/623089; 20130089899
Rational re-design of the substrate binding site of flavocytochrome P450 BM3
journal, December 2000
- Ost, Tobias W. B.; Miles, Caroline S.; Murdoch, Jane
- FEBS Letters, Vol. 486, Issue 2, p. 173-177
Characterization of Rabbit Liver Cytochrome P-450 (Laurate ω-1 Hydroxylase) Synthesized in Transformed Yeast Cells
journal, January 1988
- Imai, Yoshio
- The Journal of Biochemistry, Vol. 103, Issue 1, p. 143-148
A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation
journal, February 1997
- Oliver, Catherine F.; Modi, Sandeep; Sutcliffe, Michael J.
- Biochemistry, Vol. 36, Issue 7, p. 1567-1572
Production of high levels of 8:0 and 10:0 fatty acids in transgenic canola by overexpression of Ch FatB2, a thioesterase cDNA from Cuphea hookeriana
journal, February 1996
- Dehesh, Katayoon; Jones, Aubrey; Knutzon, Deborah S.
- The Plant Journal, Vol. 9, Issue 2, p. 167-172
Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering.
journal, November 1995
- Yuan, L.; Voelker, T. A.; Hawkins, D. J.
- Proceedings of the National Academy of Sciences, Vol. 92, Issue 23, p. 10639-10643
Analyzing Lipid Metabolism: Activation and β-Oxidation of Fatty Acids
book, January 2009
- Wheeler, Paul Robert; Parish, Tanya; Brown, Amanda Claire
- Mycobacteria Protocols, p. 47-59