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Title: Host cells and methods for producing diacid compounds

Abstract

The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1436519
Patent Number(s):
9951345
Application Number:
13/900,397
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 May 22
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., and Keasling, Jay D.. Host cells and methods for producing diacid compounds. United States: N. p., 2018. Web.
Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., & Keasling, Jay D.. Host cells and methods for producing diacid compounds. United States.
Steen, Eric J., Fortman, Jeffrey L., Dietrich, Jeffrey A., and Keasling, Jay D.. Tue . "Host cells and methods for producing diacid compounds". United States. https://www.osti.gov/servlets/purl/1436519.
@article{osti_1436519,
title = {Host cells and methods for producing diacid compounds},
author = {Steen, Eric J. and Fortman, Jeffrey L. and Dietrich, Jeffrey A. and Keasling, Jay D.},
abstractNote = {The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}
}

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Works referenced in this record:

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Storage Lipid Synthesis Is Non-essential in Yeast
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