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Title: Centromere/kinetochore protein genes for cancer diagnosis, prognosis and treatment selection

Abstract

The invention described in the application relates to a panel of gene expression markers for patient with a tumor. The invention thus provides methods and compositions, e.g., kits, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of disease progression or response to chemotherapy or radiation therapy. Such information can be used in determining prognosis and treatment options for cancer patients.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1925056
Patent Number(s):
11434535
Application Number:
15/312,138
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC02-05CH11231; R01CA116481; R01GM066272; R01GM119011
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/18/2015
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Zhang, Weiguo, Karpen, Gary, and Mao, Jian-Hua. Centromere/kinetochore protein genes for cancer diagnosis, prognosis and treatment selection. United States: N. p., 2022. Web.
Zhang, Weiguo, Karpen, Gary, & Mao, Jian-Hua. Centromere/kinetochore protein genes for cancer diagnosis, prognosis and treatment selection. United States.
Zhang, Weiguo, Karpen, Gary, and Mao, Jian-Hua. Tue . "Centromere/kinetochore protein genes for cancer diagnosis, prognosis and treatment selection". United States. https://www.osti.gov/servlets/purl/1925056.
@article{osti_1925056,
title = {Centromere/kinetochore protein genes for cancer diagnosis, prognosis and treatment selection},
author = {Zhang, Weiguo and Karpen, Gary and Mao, Jian-Hua},
abstractNote = {The invention described in the application relates to a panel of gene expression markers for patient with a tumor. The invention thus provides methods and compositions, e.g., kits, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of disease progression or response to chemotherapy or radiation therapy. Such information can be used in determining prognosis and treatment options for cancer patients.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 06 00:00:00 EDT 2022},
month = {Tue Sep 06 00:00:00 EDT 2022}
}

Works referenced in this record:

Modulators of Hec1 activity and methods therefor
patent-application, July 2013


Low density micro-array analysis in human breast cancer
patent-application, September 2004


Biomarkers for the prognosis and high-grade glioma clinical outcome
patent-application, May 2012


Nucleic acid probes for detection and/or quantitation of non-viral organisms
patent, July 1996


Method for identifying novel minor histocompatibility antigens
patent-application, August 2015


Engineered kinetochores and uses thereof
patent-application, October 2013


Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program
journal, July 2014


Gene expression profiles to predict breast cancer outcomes
patent-application, June 2011


Oligonucleotides
patent, June 2003


Cancer Specific Mitotic Network
patent-application, August 2012