Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma

Jurisson, Silvia S.; Quinn, Thomas P.; Giblin, Michael F.

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Title: Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma

Abstract

A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is administered to the body in an amount sufficient to allow uptake and retention by the tumor cells.

Inventors:: Jurisson, Silvia S.; Quinn, Thomas P.; Giblin, Michael F.

Issue Date:: Tue Jan 20 00:00:00 EST 2004

Research Org.:: Univ. of Missouri, Columbia, MO (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531467

Patent Number(s):: 6680045

Application Number:: 09/841,407

Assignee:: The Curators of the University of Missouri (Columbia, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/08 - Peptides, e.g. proteins {, carriers being peptides, polyamino acids, proteins}
A61K51/086 - {the peptide being alphaMSH, alpha melanocyte stimulating hormone}
A61K51/088 - {conjugates with carriers being peptides, polyamino acids, proteins

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DOE Contract Number:: FG02-93ER61661

Resource Type:: Patent

Resource Relation:: Patent File Date: 2001-04-24

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Jurisson, Silvia S., Quinn, Thomas P., and Giblin, Michael F. Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma.  United States: N. p., 2004. 
        Web.

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                    Jurisson, Silvia S., Quinn, Thomas P., & Giblin, Michael F. Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma.  United States.

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                    Jurisson, Silvia S., Quinn, Thomas P., and Giblin, Michael F. Tue .  
        "Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma".  United States.  https://www.osti.gov/servlets/purl/1531467.

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@article{osti_1531467,

  title        = {Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma},

  author       = {Jurisson, Silvia S. and Quinn, Thomas P. and Giblin, Michael F.},

  abstractNote = {A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is administered to the body in an amount sufficient to allow uptake and retention by the tumor cells.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 20 00:00:00 EST 2004},

  month        = {Tue Jan 20 00:00:00 EST 2004}

}

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Works referenced in this record:

Cyclic Melanotropins. 9. 7-D-Phenylalanine Analogues of the Active-Site Sequence
journal, May 1985

Cody, Wayne L.; Mahoney, Mark; Knittel, James J.
Journal of Medicinal Chemistry, Vol. 28, Issue 5
https://doi.org/10.1021/jm50001a008

Synthesis and Characterization of Rhenium-Complexed α-Melanotropin Analogs
journal, May 1997

Giblin, Michael F.; Jurisson, Silvia S.; Quinn, Thomas P.
Bioconjugate Chemistry, Vol. 8, Issue 3
https://doi.org/10.1021/bc9700291