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Title: Compositions and methods for inhibiting kinase activity

Abstract

The present invention features therapeutic compositions comprising an agent that specifically binds to a PIF pocket of Aurora A kinase and an agent that specifically binds to an ATP-binding site of Aurora A kinase, and the use of the therapeutic compositions to modulate Aurora A kinase for the treatment of cancer.

Inventors:
;
Issue Date:
Research Org.:
Brandeis Univ., Waltham, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1892675
Patent Number(s):
11266616
Application Number:
16/075,550
Assignee:
Brandeis University (Waltham, MA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-05ER15699; GM096053; GM100966-01
Resource Type:
Patent
Resource Relation:
Patent File Date: 02/08/2017
Country of Publication:
United States
Language:
English

Citation Formats

Kern, Douglas, and Zorba, Adelajda. Compositions and methods for inhibiting kinase activity. United States: N. p., 2022. Web.
Kern, Douglas, & Zorba, Adelajda. Compositions and methods for inhibiting kinase activity. United States.
Kern, Douglas, and Zorba, Adelajda. Tue . "Compositions and methods for inhibiting kinase activity". United States. https://www.osti.gov/servlets/purl/1892675.
@article{osti_1892675,
title = {Compositions and methods for inhibiting kinase activity},
author = {Kern, Douglas and Zorba, Adelajda},
abstractNote = {The present invention features therapeutic compositions comprising an agent that specifically binds to a PIF pocket of Aurora A kinase and an agent that specifically binds to an ATP-binding site of Aurora A kinase, and the use of the therapeutic compositions to modulate Aurora A kinase for the treatment of cancer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {3}
}

Works referenced in this record:

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
journal, July 2016


Crystal structure of Aurora-2 protein and binding pockets thereof
patent-application, May 2011


A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
journal, March 2010


Allosteric Protein Kinase Modulators
patent-application, February 2012


CEP: a conformational epitope prediction server
journal, July 2005


Crystals of an Aurora-A Tpx2 Complex, Tpx2 Binding Site of Aurora-A, Aurora-A Ligands and Their Use
patent-application, February 2008


Crystal structure of enzyme and uses thereof
patent-application, April 2006


Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
journal, June 2016


The epitope space of the human proteome
journal, April 2008


Molecular Affinity Clamp Technology and Uses Thereof
patent-application, June 2011


Danusertib, an aurora kinase inhibitor
journal, January 2012