Compositions and methods for modulating kinase activity
Abstract
The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.
- Inventors:
- Issue Date:
- Research Org.:
- Brandeis Univ., Waltham, MA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1840386
- Patent Number(s):
- 11104741
- Application Number:
- 15/774,747
- Assignee:
- Brandeis University (Waltham, MA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- FG02-05ER15699; GM096053; GM100966-01
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 01/27/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kern, Dorothee, and Zorba, Adelajda. Compositions and methods for modulating kinase activity. United States: N. p., 2021.
Web.
Kern, Dorothee, & Zorba, Adelajda. Compositions and methods for modulating kinase activity. United States.
Kern, Dorothee, and Zorba, Adelajda. Tue .
"Compositions and methods for modulating kinase activity". United States. https://www.osti.gov/servlets/purl/1840386.
@article{osti_1840386,
title = {Compositions and methods for modulating kinase activity},
author = {Kern, Dorothee and Zorba, Adelajda},
abstractNote = {The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 31 00:00:00 EDT 2021},
month = {Tue Aug 31 00:00:00 EDT 2021}
}
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