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Title: Compositions and methods for adoptive and active immunotherapy

Abstract

Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.

Inventors:
;
Issue Date:
Research Org.:
ORISE (Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1117675
Patent Number(s):
8,629,098
Application Number:
12/812,304
Assignee:
Yale University (New Haven, CT)
DOE Contract Number:  
AC05-06OR23100
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Jul 30
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Fahmy, Tarek, and Steenblock, Erin. Compositions and methods for adoptive and active immunotherapy. United States: N. p., 2014. Web.
Fahmy, Tarek, & Steenblock, Erin. Compositions and methods for adoptive and active immunotherapy. United States.
Fahmy, Tarek, and Steenblock, Erin. Tue . "Compositions and methods for adoptive and active immunotherapy". United States. https://www.osti.gov/servlets/purl/1117675.
@article{osti_1117675,
title = {Compositions and methods for adoptive and active immunotherapy},
author = {Fahmy, Tarek and Steenblock, Erin},
abstractNote = {Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {1}
}

Patent:

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