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Title: Compositions and methods for adoptive and active immunotherapy

Abstract

Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.

Inventors:
;
Issue Date:
Research Org.:
ORISE (Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1117675
Patent Number(s):
8629098
Application Number:
12/812,304
Assignee:
Yale University (New Haven, CT)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC05-06OR23100
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Jul 30
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Fahmy, Tarek, and Steenblock, Erin. Compositions and methods for adoptive and active immunotherapy. United States: N. p., 2014. Web.
Fahmy, Tarek, & Steenblock, Erin. Compositions and methods for adoptive and active immunotherapy. United States.
Fahmy, Tarek, and Steenblock, Erin. Tue . "Compositions and methods for adoptive and active immunotherapy". United States. https://www.osti.gov/servlets/purl/1117675.
@article{osti_1117675,
title = {Compositions and methods for adoptive and active immunotherapy},
author = {Fahmy, Tarek and Steenblock, Erin},
abstractNote = {Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {1}
}

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Works referenced in this record:

Tuning tumor-specific T-cell activation: a matter of costimulation?
journal, May 2002


Controlled-Release Vaccines-Biodegradable Polylactide/Polyglycolide (PL/PG) Microspheres as Antigen Vehicles
journal, February 1992


Biodegradation and biocompatibility of PLA and PLGA microspheres
journal, December 2012


Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes
journal, March 1984


A New Long-Acting Injectable Microcapsule System for the Administration of Progesterone
journal, May 1979


New long-acting injectable microcapsule contraceptive system
journal, October 1979


Characterization of Drug-Loaded Poly(d,l-lactide) Microspheres
journal, December 1984


An endogenously synthesized decamer peptide efficiently primes cytotoxic T cells specific for the HIV-1 envelope glycoprotein
journal, November 1993


Antigen processing for presentation by MHC class I molecules
journal, February 1992


Particulate delivery systems for biodefense subunit vaccines
journal, June 2005


The Influence Of Adjuvant On The Therapeutic Efficacy Of A Recombinant Genital Herpes Vaccine
journal, November 1994


Co-stimulation in T cell responses
journal, June 1997


Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells: Dissociating Proliferation and Development of Effector Function
journal, May 2003


B7-1-dependent co-stimulation results in qualitatively and quantitatively different responses by CD4+ and CD8+ T cells
journal, March 1997


Adoptive-cell-transfer therapy for the treatment of patients with cancer
journal, September 2003


Increased TCR Avidity after T Cell Activation
journal, February 2001


Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting
journal, October 2005


Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.
journal, March 1990


Amino acid substitution matrices from protein blocks.
journal, November 1992


T cell receptor antagonist peptides induce positive selection
journal, January 1994


Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles
journal, January 2007


Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
journal, January 2005


Alloantigen-Induced CD25 + CD4 + Regulatory T Cells Can Develop In Vivo from CD25 CD4 + Precursors in a Thymus-Independent Process
journal, January 2004


The ABCs of artificial antigen presentation
journal, March 2004


Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
journal, June 1988


Single-step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity
journal, December 1986


New advances in microsphere-based single-dose vaccines
journal, October 1997


Polymers for the sustained release of proteins and other macromolecules
journal, October 1976


Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells
journal, April 2000


Antigen presentation: Coming out gracefully
journal, August 1998


Cd28/B7 System of t cell Costimulation
journal, April 1996


Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
journal, January 2002


HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells
journal, January 2003


Novel microcapsules for delivery systems
journal, October 1987


CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities
journal, December 2001


Self-Ignorance in the Peripheral T-Cell Pool
journal, June 1993


Phase I Trial of Adoptive Immunotherapy With Cytolytic T Lymphocytes Immunized Against a Tyrosinase Epitope
journal, February 2002


A general method applicable to the search for similarities in the amino acid sequence of two proteins
journal, March 1970


Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation
journal, April 1994


Spinning molecular immunology into successful immunotherapy
journal, April 2002


Artificial antigen-presenting cells as a tool to exploit the immune `synapse'
journal, December 2000


The Central Effectors of cell Death in the Immune System
journal, April 1999


Peripheral selection of the T cell repertoire
journal, March 1991


The Use of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus Induced Lymphoma in Transplant Recipients
journal, January 2000


Cytokine control of memory T-cell development and survival
journal, April 2003


A cell culture model for T lymphocyte clonal anergy
journal, June 1990


Needles in haystacks: identifying specific peptide antigens for T cells
journal, April 1996


Bispecific antibody: a tool for diagnosis and treatment of disease
journal, March 1990


Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy
journal, April 2009


T-Cell Activation by Soluble MHC Oligomers Can Be Described by a Two-Parameter Binding Model
journal, November 2001


Multi-epitope DNA vaccines
journal, August 1997


Dual Function of Drosophila Cells as APCs for Naive CD8+ T Cells: Implications for Tumor Immunotherapy
journal, June 1996


Activation of antigen-specific T cells by artificial cell constructs having immobilized multimeric peptide–class I complexes and recombinant B7–Fc proteins
journal, March 2001


Exosomes: composition, biogenesis and function
journal, August 2002


Antigen Recognition by Class I-Restricted T Lymphocytes
journal, April 1989


How LCR Works
journal, November 1991


Processing of bacterial antigens for peptide presentation on MHC class I molecules
journal, December 1999


In vivo biocompatibility studies of medisorb® 65/35 D,L-lactide/glycolide copolymer microspheres
journal, May 1993