Title: Compositions and methods for adoptive and active immunotherapy

Abstract

Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.

Inventors:

Fahmy, Tarek; Steenblock, Erin

Issue Date:

2014-01-14

Research Org.:

ORISE (Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States))

Sponsoring Org.:

USDOE

OSTI Identifier:

1117675

Patent Number(s):

8629098

Application Number:

12/812,304

Assignee:

Yale University (New Haven, CT)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2039/5158 - {Antigen-pulsed cells, e.g. T-cells}
A61K2039/55516 - {Proteins
A61K2039/55533 - {IL-2}
A61K2039/55555 - {Liposomes
A61K39/39 - characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K47/6425 - {the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell}
A61K47/646 - {the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines}
A61K47/6925 - {the form being a microcapsule, nanocapsule, microbubble or nanobubble}
A61K47/6935 - {the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol}
A61K9/1647 - {Polyesters, e.g. poly

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00 - Antineoplastic agents
A61P37/00 - Drugs for immunological or allergic disorders
A61P37/06 - Immunosuppressants, e.g. drugs for graft rejection
A61P37/08 - Antiallergic agents

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N2501/23 - Interleukins [IL]
C12N2501/51 - B7 molecules, e.g. CD80, CD86, CD28
C12N2501/515 - CD3, T-cell receptor complex
C12N2531/00 - Microcarriers
C12N2533/40 - Polyhydroxyacids, e.g. polymers of glycolic or lactic acid
C12N5/0636 - {T lymphocytes}

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DOE Contract Number:  

AC05-06OR23100

Resource Type:

Patent

Resource Relation:

Patent File Date: 2009 Jul 30

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES