Keto-isovalerate decarboxylase enzymes and methods of use thereof
Abstract
Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.
- Inventors:
- Issue Date:
- Research Org.:
- Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1236558
- Patent Number(s):
- 9238828
- Application Number:
- 13/560,147
- Assignee:
- Butamax Advanced Biofuels LLC
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AR0000006
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Jul 27
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES
Citation Formats
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States: N. p., 2016.
Web.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, & He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Tue .
"Keto-isovalerate decarboxylase enzymes and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1236558.
@article{osti_1236558,
title = {Keto-isovalerate decarboxylase enzymes and methods of use thereof},
author = {McElvain, Jessica and O'Keefe, Daniel P. and Paul, Brian James and Payne, Mark S. and Rothman, Steven Cary and He, Hongxian},
abstractNote = {Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 19 00:00:00 EST 2016},
month = {Tue Jan 19 00:00:00 EST 2016}
}
Works referenced in this record:
Use of the valine biosynthetic pathway to convert glucose into isobutanol
journal, December 2010
- Savrasova, Ekaterina A.; Kivero, Aleksander D.; Shakulov, Rustem S.
- Journal of Industrial Microbiology & Biotechnology, Vol. 38, Issue 9
Biochemical and molecular characterization of α-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids by Lactococcus lactis
journal, September 2004
- Plaza, Marta; Fernández de Palencia, Pilar; Peláez, Carmen
- FEMS Microbiology Letters, Vol. 238, Issue 2
Branched-Chain Keto Acid Decarboxylase from Lactococcus lactis (KdcA), a Valuable Thiamine Diphosphate-Dependent Enzyme for Asymmetric C-C Bond Formation
journal, June 2007
- Gocke, Dörte; Nguyen, Cong Luan; Pohl, Martina
- Advanced Synthesis & Catalysis, Vol. 349, Issue 8-9, p. 1425-1435
Application of α-keto acid decarboxylases in biotransformations
journal, June 1998
- Iding, H.; Siegert, P.; Mesch, K.
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1385, Issue 2
Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes
journal, July 2009
- Atsumi, Shota; Wu, Tung-Yun; Eckl, Eva-Maria
- Applied Microbiology and Biotechnology, Vol. 85, Issue 3
Aspartate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase
journal, April 1999
- Chang, Alan K.; Nixon, Peter F.; Duggleby, Ronald G.
- Biochemical Journal, Vol. 339, Issue 2
The role of induced fit and conformational changes of enzymes in specificity and catalysis
journal, March 1988
- Herschlag, Daniel
- Bioorganic Chemistry, Vol. 16, Issue 1, p. 62-96
Identification, Cloning, and Characterization of a Lactococcus lactis Branched-Chain  -Keto Acid Decarboxylase Involved in Flavor Formation
journal, January 2005
- Smit, B. A.; van Hylckama Vlieg, J. E. T.; Engels, W. J. M.
- Applied and Environmental Microbiology, Vol. 71, Issue 1
Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase
journal, December 2006
- Yep, Alejandra; Kenyon, George L.; McLeish, Michael J.
- Bioorganic Chemistry, Vol. 34, Issue 6, p. 325-336
Solvent tolerant microorganisms and methods of isolation
patent, June 2009
- Bramucci, Michael G.; Nagarajan, Vasantha; Sedkova, Natalia
- US Patent Document 7,541,173
Fermentive production of four carbon alcohols
patent, December 2010
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 7,851,188
Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
patent, March 2011
- Liao, Der-Ing; Nelson, Mark J.; Bramucci, Michael G.
- US Patent Document 7,910,342
Fermentive production of four carbon alcohols
patent, August 2011
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 7,993,889
Solvent tolerant microorganisms
patent, September 2011
- Bramucci, Michael G.; Kane, Helene M. A.; Nagarajan, Vasantha
- US Patent Document 8,017,364
Ketol-acid reductoisomerase using NADH
patent, March 2012
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,129,162
Fermentive production of four carbon alcohols
patent, May 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,178,328
Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
patent, May 2012
- Bramucci, Michael G.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,188,250
Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
patent, June 2012
- Eliot, Andrew C.; Nagarajan, Vasantha; Huang, Lixuan Lisa
- US Patent Document 8,206,970
Ketol-acid reductoisomerase using NADH
patent, July 2012
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,222,017
Recombinant yeast host cell with Fe-S cluster proteins and methods of using thereof
patent, August 2012
- Anthony, Larry Cameron; Flint, Dennis; Suh, Wonchul
- US Patent Document 8,241,878
Fermentive production of four carbon alcohols
patent, September 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,273,558
Fermentive production of four carbon alcohols
patent, October 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,283,144
Production of four carbon alcohols using improved strain
patent, February 2013
- Larossa, Robert A.; Smulski, Dana R.; Nagarajan, Vasantha
- US Patent Document 8,372,612
Yeast strain for production of four carbon alcohols
patent, March 2013
- Larossa, Robert A.
- US Patent Document 8,389,252
Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
patent, June 2013
- Paul, Brian James
- US Patent Document 8,455,224
Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
patent, June 2013
- Bramucci, Michael G.; Larossa, Robert A.; Smulski, Dana R.
- US Patent Document 8,455,225
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
patent, June 2013
- Anthony, Larry Cameron
- US Patent Document 8,465,964
Strain comprising increased expression of a CFA coding region for butanol production
patent, August 2013
- Flint, Dennis; Larossa, Robert A.; Nagarajan, Vasantha
- US Patent Document 8,518,678
Yeast with increased butanol tolerance involving filamentous growth response
patent, October 2013
- Bramucci, Michael G.; Larossa, Robert A.; Singh, Manjari
- US Patent Document 8,557,562
Yeast with increased butanol tolerance involving a multidrug efflux pump gene
patent, December 2013
- Van Dyk, Tina K.
- US Patent Document 8,614,085
Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
patent, January 2014
- Paul, Brian James; Suh, Wonchul
- US Patent Document 8,637,281
Expression of hexose kinase in recombinant host cells
patent, January 2014
- Anthony, Larry Cameron; Kruckeberg, Arthur Leo
- US Patent Document 8,637,289
Strain for butanol production with increased membrane unsaturated trans fatty acids
patent, February 2014
- Flint, Dennis; Van Dyk, Tina K.
- US Patent Document 8,652,823
Enhanced pyruvate to acetolactate conversion in yeast
patent, March 2014
- Anthony, Larry Cameron; Maggio-Hall, Lori Ann
- US Patent Document 8,669,094
Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
patent, April 2014
- Bramucci, Michael G.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,691,540
Fermentive production of four carbon alcohols
patent, May 2014
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,735,114
Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
patent, July 2014
- Satagopan, Sriram; O'Keefe, Daniel P.; Gude, Janardhan
- US Patent Document 8,765,433
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
patent, July 2014
- Anthony, Larry Cameron
- US Patent Document 8,785,166
Yeast with increased butanol tolerance involving cell wall integrity pathway
patent, August 2014
- Bramucci, Michael G.; Larossa, Robert A.; Smulski, Dana R.
- US Patent Document 8,795,992
Production of isobutanol in yeast mitochondria
patent, September 2014
- Anthony, Larry Cameron; Huang, Lixuan Lisa; Ye, Rick W.
- US Patent Document 8,828,694
Fermentive production of four carbon alcohols
patent, September 2014
- Donaldson, Gail K.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,828,704
Fermentive Production Of Four Carbon Alcohols
patent-application, July 2008
- Donaldson, Gail K.; Huang, Lixuan Lisa; Maggio-Hall, Lori Ann
- US Patent Application 11/527995; 20080182308
Identification and use of Bacterial [2FE-2S] Dihydroxy-acid Dehydratases
patent-application, April 2010
- Flint, Dennis; Rothman, Steven Cary; Suh, Wonchul
- US Patent Application 12/569636; 20100081154
Enhanced Iron-sulfur Cluster Formation for Increased Dihydroxy-Acid Dehydratase Activity in Lactic Acid Bacteria
patent-application, April 2010
- Paul, Brain James; Suh, Wonchul
- US Patent Application 12/569103; 20100081182
Carbon Pathway Optimized Production Hosts for the Production of Isobutanol
patent-application, May 2010
- Anthony, Larry Cameron; Dauner, Michael; Donaldson, Gail K.
- US Patent Application 12/606410; 20100120105
Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol
patent-application, March 2011
- Urano, Jun; Dundon, Catherine Asleson; Meinhold, Peter
- US Patent Application 12/855276; 20110076733
Bacterial Strains for Butanol Production
patent-application, August 2011
- Euler, Lori Jean; Flint, Dennis; Paul, Brian James
- US Patent Application 12/899760; 20110195505
Fermentive Production of Isobutanol Using Highly Effective Ketol-acid Reductoisomerase Enzymes
patent-application, October 2011
- Nagarajan, Vasantha; Paul, Brian James; Suh, Wonchul
- US Patent Application 12/893077; 20110244536
Engineering Resistance to Aliphatic Alcohols
patent-application, March 2012
- Alsaker, Keith; Grenfell-Lee, Daniel; Hudson, Michael
- US Patent Application 13/214310; 20120058541
Recombinant host cells comprising phosphoketolases
patent-application, June 2012
- Dauner, Michael; Maggio-Hall, Lori Ann; Tomb, Jean-Francois
- US Patent Application 13/161168; 20120156735
Fermentive Production of Four Carbon Alcohols
patent-application, August 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Nagarajan, Vasantha
- US Patent Application 13/281872; 20120196341
Lignocellulosic Hydrolysates as Feedstocks for Isobutanol Fermentation
patent-application, February 2013
- Dobson, Ian David; Kruckeberg, Arthur Leo
- US Patent Application 13/525032; 20130035515
Acetate Supplementation of Medium for Butanologens
patent-application, September 2013
- Maggio-Hall, Lori Ann
- US Patent Application 13/833369; 20130252296
Host Cells and Methods for Production of Isobutanol
patent-application, January 2014
- Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa
- US Patent Application 13/840649; 20140030782
Host Cells and Methods for Production of Isobutanol
patent-application, January 2014
- Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa
- US Patent Application 13/840676; 20140030783
Activity of FE-S Cluster Requiring Proteins
patent-application, February 2014
- Flint, Dennis; Paul, Brian James; Ye, Rick W.
- US Patent Application 13/837921; 20140038263
Dhad Variants for Butanol Production
patent-application, July 2014
- Maggio-Hall, Loriann Ann; Paul, Brian James; Rothman, Steven Cary
- US Patent Application 14/142,398; 2014/0186910 Al