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Title: Process for the production of 18F-2-deoxy-2-fluoro-D-glucose

Abstract

Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding 18F-compound by the reaction of acetyl hypofluorite or the corresponding 18F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176553
Patent Number(s):
H000074
Application Number:
06/469597
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Patent File Date: 1983 Feb 24
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; statutory invention registration

Citation Formats

Shiue, Chyng-Yann, Salvadori, Piero A., Wolf, Alfred P., Fowler, Joanna S., and MacGregor, Robert R. Process for the production of 18F-2-deoxy-2-fluoro-D-glucose. United States: N. p., 1986. Web.
Shiue, Chyng-Yann, Salvadori, Piero A., Wolf, Alfred P., Fowler, Joanna S., & MacGregor, Robert R. Process for the production of 18F-2-deoxy-2-fluoro-D-glucose. United States.
Shiue, Chyng-Yann, Salvadori, Piero A., Wolf, Alfred P., Fowler, Joanna S., and MacGregor, Robert R. Tue . "Process for the production of 18F-2-deoxy-2-fluoro-D-glucose". United States. https://www.osti.gov/servlets/purl/1176553.
@article{osti_1176553,
title = {Process for the production of 18F-2-deoxy-2-fluoro-D-glucose},
author = {Shiue, Chyng-Yann and Salvadori, Piero A. and Wolf, Alfred P. and Fowler, Joanna S. and MacGregor, Robert R.},
abstractNote = {Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding 18F-compound by the reaction of acetyl hypofluorite or the corresponding 18F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {5}
}

Works referenced in this record:

Author index for volume 22
journal, November 1981


Acetyl hypofluorite, the first member of a new family of organic compounds
journal, January 1981


Fluorination with molecular fluorine. A convenient synthesis of 2-deoxy-2-fluoro-D-glucose
journal, June 1977


A rapid, stereospecific synthesis of 2-deoxy-2-fluoro-D-glucose using the fluoride ion
journal, January 1982