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Title: Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose

Abstract

Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.

Inventors:
 [1];  [2];  [3];  [4]
  1. Brookline, MA
  2. Jerusalem, IL
  3. East Setauket, NY
  4. Setauket, NY
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
866024
Patent Number(s):
4617386
Assignee:
United States of America as represented by United States (Washington, DC)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
process; production; sup18; f-2-deoxy-2-fluoro-d-glucose; 2-deoxy-2-fluoro-d-glucose; corresponding; f-compound; methyl; 46-o-benzylidine-3-o-methyl-2-o-trifluoromethanesulfonyl-beta-d-mannopy; ranoside; reacted; triflating; reagent; resulting; compound; cshfsub2; rbf; f-compounds; thereafter; alkyl; removed; hydrolysis; /999/

Citation Formats

Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, and Wolf, Alfred P. Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose. United States: N. p., 1986. Web.
Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, & Wolf, Alfred P. Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose. United States.
Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, and Wolf, Alfred P. Wed . "Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose". United States. https://www.osti.gov/servlets/purl/866024.
@article{osti_866024,
title = {Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose},
author = {Elmaleh, David R and Levy, Shlomo and Shiue, Chyng-Yann and Wolf, Alfred P},
abstractNote = {Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {1}
}

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