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Title: Process for the production of 18F-2-deoxy-2-fluoro-D-glucose

Abstract

Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound by the reaction of acetyl hypofluorite or the corresponding .sup.18 F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. East Setauket, NY
  2. Pisa, IT
  3. Setauket, NY
  4. Bellport, NY
  5. Sag Harbor, NY
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
875247
Patent Number(s):
H74
Assignee:
United States of America as represented by United States ()
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
process; production; 18f-2-deoxy-2-fluoro-d-glucose; 2-deoxy-2-fluoro-d-glucose; corresponding; 18; f-compound; reaction; acetyl; hypofluorite; 6-tri-o-acetyl-d-glucal; followed; hydrolysis; compound; ambient; temperature; ambient temperature; acetyl hypofluorite; /999/

Citation Formats

Shiue, Chyng-Yann, Salvadori, Piero A, Wolf, Alfred P, Fowler, Joanna S, and MacGregor, Robert R. Process for the production of 18F-2-deoxy-2-fluoro-D-glucose. United States: N. p., 1986. Web.
Shiue, Chyng-Yann, Salvadori, Piero A, Wolf, Alfred P, Fowler, Joanna S, & MacGregor, Robert R. Process for the production of 18F-2-deoxy-2-fluoro-D-glucose. United States.
Shiue, Chyng-Yann, Salvadori, Piero A, Wolf, Alfred P, Fowler, Joanna S, and MacGregor, Robert R. Wed . "Process for the production of 18F-2-deoxy-2-fluoro-D-glucose". United States. https://www.osti.gov/servlets/purl/875247.
@article{osti_875247,
title = {Process for the production of 18F-2-deoxy-2-fluoro-D-glucose},
author = {Shiue, Chyng-Yann and Salvadori, Piero A and Wolf, Alfred P and Fowler, Joanna S and MacGregor, Robert R},
abstractNote = {Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound by the reaction of acetyl hypofluorite or the corresponding .sup.18 F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {1}
}

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