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Title: Functional nucleic acid probes and uses thereof

Abstract

The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.

Inventors:
Issue Date:
Research Org.:
Iowa State Univ., Ames, IA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175921
Patent Number(s):
7115369
Application Number:
10/096,872
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
W-7405-ENG-82
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Nilsen-Hamilton, Marit. Functional nucleic acid probes and uses thereof. United States: N. p., 2006. Web.
Nilsen-Hamilton, Marit. Functional nucleic acid probes and uses thereof. United States.
Nilsen-Hamilton, Marit. Tue . "Functional nucleic acid probes and uses thereof". United States. https://www.osti.gov/servlets/purl/1175921.
@article{osti_1175921,
title = {Functional nucleic acid probes and uses thereof},
author = {Nilsen-Hamilton, Marit},
abstractNote = {The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {10}
}

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Works referenced in this record:

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Adaptive Recognition by Nucleic Acid Aptamers
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