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Title: Chemical micro-sensor

Abstract

An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by electrophoresis. The thermally-induced change in the index of refraction of light in said electrophoresis capillary is monitored using an integrated micro-interferometer. The interferometer includes a first interferometer arm intersecting the electrophoresis capillary proximate the excitation beam and a second, reference interferometer arm. Changes in index of refraction in the analyte measured by interrogating the interferometer state using white light interferometry and a phase-generated carrier demodulation technique. Background thermo-optical activity in the buffer solution is cancelled by splitting the pump beam and exciting pure buffer solution in a second section of capillary where it crosses the reference arm of the interferometer.

Inventors:
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175336
Patent Number(s):
6887359
Application Number:
09/877,961
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G01 - MEASURING G01B - MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Ruggiero, Anthony J. Chemical micro-sensor. United States: N. p., 2005. Web.
Ruggiero, Anthony J. Chemical micro-sensor. United States.
Ruggiero, Anthony J. Tue . "Chemical micro-sensor". United States. https://www.osti.gov/servlets/purl/1175336.
@article{osti_1175336,
title = {Chemical micro-sensor},
author = {Ruggiero, Anthony J.},
abstractNote = {An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by electrophoresis. The thermally-induced change in the index of refraction of light in said electrophoresis capillary is monitored using an integrated micro-interferometer. The interferometer includes a first interferometer arm intersecting the electrophoresis capillary proximate the excitation beam and a second, reference interferometer arm. Changes in index of refraction in the analyte measured by interrogating the interferometer state using white light interferometry and a phase-generated carrier demodulation technique. Background thermo-optical activity in the buffer solution is cancelled by splitting the pump beam and exciting pure buffer solution in a second section of capillary where it crosses the reference arm of the interferometer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {5}
}

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Works referenced in this record:

Laser-Based Double-Beam Thermal Lens Detector for Microcolumn Liquid Chromatography
journal, August 1993


Electromanipulation and separation of cells using travelling electric fields
journal, August 1996


Attomole amino acid determination by capillary zone electrophoresis with thermooptical absorbance detection
journal, January 1989


Phase fluctuation optical heterodyne spectroscopy of gases
journal, January 1981


Differential refractometry by an integrated-optical Young interferometer
journal, March 1997


Trace detection in gases using phase fluctuation optical heterodyne spectroscopy
journal, April 1980


Hologram-Based Thermooptical Absorbance Detection in Capillary Electrophoresis: Separation of Nucleosides and Nucleotides
journal, January 1995


Hologram-based refractive index detector for capillary electrophoresis: separation of metal ions
journal, January 1994