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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174766
Patent Number(s):
6706509
Application Number:
09/861,012
Assignee:
University Of California, The Regents Of
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 2004. Web.
Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein protein kinase. United States.
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue . "Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/1174766.
@article{osti_1174766,
title = {Oncoprotein protein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {3}
}

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Works referenced in this record:

Induction of protooncogene c-jun by serum growth factors.
journal, November 1988


Parallel signal processing among mammalian MAPKs
journal, March 1995


Induction of proto-oncogene JUN/AP-1 by serum and TPA
journal, August 1988


An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990


DNA-binding activity of jun is increased through its interaction with Fos
journal, April 1990


Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990


Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992


Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988


Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991