Oncoprotein protein kinase
Abstract
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1174766
- Patent Number(s):
- 6706509
- Application Number:
- 09/861,012
- Assignee:
- University Of California, The Regents Of
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- 86ER60429
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 2004.
Web.
Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein protein kinase. United States.
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue .
"Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/1174766.
@article{osti_1174766,
title = {Oncoprotein protein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {3}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase
journal, March 1988
- Lee, C.; Wu, X.; Gibbs, R.
- Science, Vol. 239, Issue 4845
Induction of protooncogene c-jun by serum growth factors.
journal, November 1988
- Ryder, K.; Nathans, D.
- Proceedings of the National Academy of Sciences, Vol. 85, Issue 22
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
journal, October 1994
- Minden, A.; Lin, A.; Smeal, T.
- Molecular and Cellular Biology, Vol. 14, Issue 10
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
journal, November 1993
- Hibi, M.; Lin, A.; Smeal, T.
- Genes & Development, Vol. 7, Issue 11
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
journal, December 1987
- Bohmann, D.; Bos, T.; Admon, A.
- Science, Vol. 238, Issue 4832
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
journal, May 1991
- Boulton, Teri G.; Nye, Steven H.; Robbins, David J.
- Cell, Vol. 65, Issue 4
Parallel signal processing among mammalian MAPKs
journal, March 1995
- Cano, Eva; Mahadevan, Louis C.
- Trends in Biochemical Sciences, Vol. 20, Issue 3
Induction of proto-oncogene JUN/AP-1 by serum and TPA
journal, August 1988
- Lamph, William W.; Wamsley, Penny; Sassone-Corsi, Paolo
- Nature, Vol. 334, Issue 6183
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
journal, March 1994
- Dérijard, Benoit; Hibi, Masahiko; Wu, I-Huan
- Cell, Vol. 76, Issue 6
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990
- Boulton, T.; Yancopoulos, G.; Gregory, J.
- Science, Vol. 249, Issue 4964
DNA-binding activity of jun is increased through its interaction with Fos
journal, April 1990
- Allegretto, Elizabeth A.; Smeal, Tod; Angel, Peter
- Journal of Cellular Biochemistry, Vol. 42, Issue 4
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990
- Anderson, Neil G.; Maller, James L.; Tonks, Nicholas K.
- Nature, Vol. 343, Issue 6259
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992
- Adler, V.; Franklin, C. C.; Kraft, A. S.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 12
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988
- Ryseck, R. -P.; Hirai, S. I.; Yaniv, M.
- Nature, Vol. 334, Issue 6182
Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991
- Pulverer, Bernd J.; Kyriakis, John M.; Avruch, Joseph
- Nature, Vol. 353, Issue 6345