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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
 [1];  [1];  [2];  [3];  [4]
  1. (San Diego, CA)
  2. (La Jolla, CA)
  3. (Princeton, MA)
  4. (Shrewsbury, MA)
Issue Date:
Research Org.:
University of California
OSTI Identifier:
875023
Patent Number(s):
6514745
Application Number:
08/220,602
Assignee:
The Regents of the University of California (Oakland, CA) OAK
DOE Contract Number:  
FG03-86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
oncoprotein; protein; kinase; isolated; polypeptide; jnk; characterized; molecular; weight; 46kd; determined; reducing; sds-page; serine; threonine; activity; phosphorylating; c-jun; n-terminal; activation; domain; polynucleotide; sequences; method; detection; provided; phosphorylates; affects; expression; ap-1; sites; molecular weight; polynucleotide sequences; isolated polypeptide; protein kinase; reducing sds-page; kinase activity; oncoprotein protein; threonine kinase; /435/999/

Citation Formats

Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, and Derijard, Benoit. Oncoprotein protein kinase. United States: N. p., 2003. Web.
Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, & Derijard, Benoit. Oncoprotein protein kinase. United States.
Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, and Derijard, Benoit. Tue . "Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/875023.
@article{osti_875023,
title = {Oncoprotein protein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning and Davis, Roger and Derijard, Benoit},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {2}
}

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