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Title: Immunostimulatory nanoparticles and related compositions, methods and systems

Abstract

Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1163992
Patent Number(s):
8889623
Application Number:
12/604,362
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Hoeprich, Paul D, Fischer, Nicholas O, Blanchette, Craig, and Mason, Peter W. Immunostimulatory nanoparticles and related compositions, methods and systems. United States: N. p., 2014. Web.
Hoeprich, Paul D, Fischer, Nicholas O, Blanchette, Craig, & Mason, Peter W. Immunostimulatory nanoparticles and related compositions, methods and systems. United States.
Hoeprich, Paul D, Fischer, Nicholas O, Blanchette, Craig, and Mason, Peter W. Tue . "Immunostimulatory nanoparticles and related compositions, methods and systems". United States. https://www.osti.gov/servlets/purl/1163992.
@article{osti_1163992,
title = {Immunostimulatory nanoparticles and related compositions, methods and systems},
author = {Hoeprich, Paul D and Fischer, Nicholas O and Blanchette, Craig and Mason, Peter W},
abstractNote = {Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {11}
}

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Works referenced in this record:

Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C
journal, September 1998


Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs
journal, June 2006


Reconstitution and Imaging of a Membrane Protein in a Nanometer-Size Phospholipid Bilayer
journal, September 1998


Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers
journal, November 2003


Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins
journal, August 2002


Bacterial Rhodopsin: Evidence for a New Type of Phototrophy in the Sea
journal, September 2000


Specific targeting of a lipophilic prodrug of iododeoxyuridine to parenchymal liver cells using lactosylated reconstituted high density lipoprotein particles
journal, July 1996


Specific Interaction and Two-Dimensional Crystallization of Histidine Tagged Yeast RNA Polymerase I on Nickel-Chelating Lipids
journal, March 1998


Atomic force microscopy differentiates discrete size distributions between membrane protein containing and empty nanolipoprotein particles
journal, March 2009


Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles
journal, July 2009


Quantifying size distributions of nanolipoprotein particles with single-particle analysis and molecular dynamic simulations
journal, April 2008


Do Recombinant Receptor Assays Provide Affinity and Provide Estimates?
journal, May 1997


Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties
journal, July 2006


Nanodiscs for Immobilization of Lipid Bilayers and Membrane Receptors: Kinetic Analysis of Cholera Toxin Binding to a Glycolipid Receptor
journal, August 2008


Osmotic shrinkage of giant egg-lecithin vesicles
journal, April 1981


Chemoselective Attachment of Biologically Active Proteins to Surfaces by Expressed Protein Ligation and Its Application for “Protein Chip” Fabrication
journal, November 2004

  • Camarero, Julio A.; Kwon, Youngeun; Coleman, Matthew A.
  • Journal of the American Chemical Society, Vol. 126, Issue 45, p. 14730-14731
  • https://doi.org/10.1021/ja0456611

Cell-free Co-expression of Functional Membrane Proteins and Apolipoprotein, Forming Soluble Nanolipoprotein Particles
journal, July 2008


CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy
journal, October 2006


Progress towards the easier use of P450 enzymes
journal, January 2006


Attaching histidine-tagged peptides and proteins to lipid-based carriers through use of metal-ion-chelating lipids
journal, December 2002


Stability of pressure-extruded liposomes made from archaeobacterial ether lipids
journal, November 1994


Different Apolipoproteins Impact Nanolipoprotein Particle Formation
journal, November 2007

  • Chromy, Brett A.; Arroyo, Erin; Blanchette, Craig D.
  • Journal of the American Chemical Society, Vol. 129, Issue 46, p. 14348-14354
  • https://doi.org/10.1021/ja074753y

Surface changes induced by osmotic shrinkage on large unilamellar vesicles
journal, November 1996


Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice
journal, February 2000


Immobilization of Active Hydrogenases by Encapsulation in Polymeric Porous Gels
journal, October 2005


Immobilization of His-Tagged Proteins on Nickel-Chelating Nanolipoprotein Particles
journal, March 2009


Conjugation to Nickel-Chelating Nanolipoprotein Particles Increases the Potency and Efficacy of Subunit Vaccines to Prevent West Nile Encephalitis
journal, June 2010


Carboxyl-Terminal Domain of Human Apolipoprotein E: Expression, Purification, and Crystallization
journal, November 1999


The shape of things to come: The Shape of Things To Come
journal, June 1996


Electron microscopic study on reassembly of plasma high density apoprotein with various lipids
journal, November 1971


Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses
journal, September 2001

  • Bacher, Gerold; Szymanski, Wladyslaw W.; Kaufman, Stanley L.
  • Journal of Mass Spectrometry, Vol. 36, Issue 9, p. 1038-1052
  • https://doi.org/10.1002/jms.208

Hydrogen Production under Aerobic Conditions by Membrane-Bound Hydrogenases from Ralstonia Species
journal, August 2008


Adjuvants for human vaccines—current status, problems and future prospects
journal, January 1995


Complex of Human Apolipoprotein C-1 with Phospholipid:  Thermodynamic or Kinetic Stability?
journal, June 2002


Pharmaceutical analysis of synthetic lipid A-based vaccine adjuvants in poly (d,l-lactic-co-glycolic acid) nanoparticle formulations
journal, August 2007


Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
journal, August 2006


Energy-Converting [NiFe] Hydrogenases from Archaea and Extremophiles: Ancestors of Complex I
journal, February 2004


Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
journal, May 2008


Influence of liposome charge and composition on their interaction with human blood serum proteins
journal, January 1993

  • Hernández-Caselles, Trinidad; Villalaín, José; Gómez-Fernández, Juan C.
  • Molecular and Cellular Biochemistry, Vol. 120, Issue 2, p. 119-126
  • https://doi.org/10.1007/BF00926084

Fabrication of biomolecule–copolymer hybrid nanovesicles as energy conversion systems
journal, November 2005


G-Protein-Coupled Receptor Microarrays for Multiplexed Compound Screening
journal, June 2006


Comparison of the Dynamics of the Primary Events of Bacteriorhodopsin in Its Trimeric and Monomeric States
journal, September 2002


Indium-111 Labeling of Low Density Lipoproteins with the DTPA−Bis(stearylamide):  Evaluation as a Potential Radiopharmaceutical for Tumor Localization
journal, January 1996


Thermotolerant Hydrogenases: Biological Diversity, Properties, and Biotechnological Applications
journal, January 2008


Functional Cell-free Synthesis of a Seven Helix Membrane Protein: In situ Insertion of Bacteriorhodopsin into Liposomes
journal, August 2007


Insertion of Membrane Proteins into Discoidal Membranes Using a Cell-Free Protein Expression Approach
journal, August 2008


Cell-free expression as an emerging technique for the large scale production of integral membrane protein
journal, September 2006


High level cell-free expression and specific labeling of integral membrane proteins
journal, February 2004


The growing impact of click chemistry on drug discovery
journal, December 2003


Steric stabilization of phospholipid vesicles by block copolymers Vesicle flocculation and osmotic swelling caused by monovalent and divalent cations
journal, January 1998

  • Kostarelos, Kostas; Luckham, Paul F.; Tadros, Tharwat F.
  • Journal of the Chemical Society, Faraday Transactions, Vol. 94, Issue 15
  • https://doi.org/10.1039/A801134F

A novel approach for biohydrogen production
journal, September 2006


Two-Dimensional Crystallization of Histidine-Tagged, HIV-1 Reverse Transcriptase Promoted by a Novel Nickel-Chelating Lipid
journal, September 1994


Novel applications of liposomes
journal, July 1998


Mechanical properties and stability measurement of cholesterol-containing liposome on mica by atomic force microscopy
journal, October 2004


Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid
journal, May 2000


Large-scale profiling of protein palmitoylation in mammalian cells
journal, January 2009


The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4
journal, June 2007


[FeFe] hydrogenases and their evolution: a genomic perspective
journal, March 2007


Functional Characterization of Apolipoprotein E Isoforms Overexpressed in Escherichia coli
journal, July 1999


Applications of Phospholipid Bilayer Nanodiscs in the Study of Membranes and Membrane Proteins
journal, February 2007


A Potent Adjuvant Monophosphoryl Lipid A Triggers Various Immune Responses, but Not Secretion of IL-1β or Activation of Caspase-1
journal, January 2006


The Difference a Se Makes? Oxygen-Tolerant Hydrogen Production by the [NiFeSe]-Hydrogenase from Desulfomicrobium baculatum
journal, October 2008


In-depth analysis of the membrane and cytosolic proteome of red blood cells
journal, August 2006


Preparation and Characterization of Nickel Nanoparticles for Binding to His-tag Proteins and Antigens
journal, December 2006


Taking toll: lipid A mimetics as adjuvants and immunomodulators
journal, October 2002


Topology prediction of membrane proteins
journal, February 1996


The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin
journal, January 2002


Comparison of Multiplexed Techniques for Detection of Bacterial and Viral Proteins
journal, August 2004


Two-Dimensional Streptavidin Crystals on Giant Lipid Bilayer Vesicles
journal, May 2002


Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
journal, January 2005


Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting
journal, April 2001


Generation of immunoliposomes using recombinant single-chain Fv fragments bound to Ni-NTA-liposomes
journal, August 2005


In vitro characterization of binding and stability of single-chain Fv Ni-NTA-liposomes
journal, January 2006


Chemistry: The photon trap
journal, March 2008


Purification and Characterization of a Membrane-Bound Hydrogenase from the Hyperthermophilic Archaeon Pyrococcus furiosus
journal, June 2000


A simple energy-conserving system: Proton reduction coupled to proton translocation
journal, June 2003


Synthesis and Characterization of Chelator-Lipids for Reversible Immobilization of Engineered Proteins at Self-Assembled Lipid Interfaces
journal, September 1994


Laboratory scale structural genomics
journal, March 2004


Molecular Dynamics Simulations of Discoidal Bilayers Assembled from Truncated Human Lipoproteins
journal, January 2005


Membrane-Mimetic Films of Asymmetric Phosphatidylcholine Lipid Bolaamphiphiles
journal, January 2006


Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems
journal, January 2003


Peptide stabilized amphotericin B nanodisks
journal, April 2007


Induction of tumor necrosis factor-α in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide
journal, January 2001


Vaccine manufacturing: challenges and solutions
journal, November 2006


Occurrence, Classification, and Biological Function of Hydrogenases:  An Overview
journal, October 2007


Investigating and Exploiting the Electrocatalytic Properties of Hydrogenases
journal, October 2007


From The Cover: Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels
journal, October 2005


CpG DNA induces stronger immune responses with less toxicity than other adjuvants
journal, March 2000


In vitro hydrogen production by glucose dehydrogenase and hydrogenase
journal, July 1996


Enzymatic production of biohydrogen: Biotechnology
journal, June 2000


High yield cell-free production of integral membrane proteins without refolding or detergents
journal, May 2008


Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3′ sequence modifications
journal, February 2003