Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems
Abstract
Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805644
- Patent Number(s):
- 10953085
- Application Number:
- 15/590,918
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA); The United States of America, Represented by the Secretary of Agriculture (Washington, DC); University of Connecticut (Farmington, CT)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/09/2017
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Jr., Paul D. Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems. United States: N. p., 2021.
Web.
Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., & Hoeprich, Jr., Paul D. Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems. United States.
Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Jr., Paul D. Tue .
"Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems". United States. https://www.osti.gov/servlets/purl/1805644.
@article{osti_1805644,
title = {Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems},
author = {Rieder, Aida Elizabeth and De Los Santos, Teresa B. and Rodriguez, Luis Miguel and Rai, Devendra and Diaz-San Segundo, Fayna C. and Hoeprich, Jr., Paul D.},
abstractNote = {Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 23 00:00:00 EDT 2021},
month = {Tue Mar 23 00:00:00 EDT 2021}
}
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Works referenced in this record:
Genetically Engineered Foot and Mouth Disease Virus and Related Proteins, Polynucleotides, Compositions, Methods and Systems
patent-application, November 2018
- Rieder, Aida E.; De Los Santos, Teresa B.; Rodriguez, Luis L.
- 15/590918; 20180326038
Method of preparing a controlled release liquid pharmaceutical composition
patent, April 1977
- Suzuki, Akira; Miura, Hiroshi; Matsuda, Saburo
- US Patent Document 4,016,100
Extrusion technique for producing unilamellar vesicles
patent, April 1991
- Cullis, Pieter R.; Hope, Michael J.; Bally, Marcel B.
- US Patent Document 5,008,050
Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems
patent-application, April 2010
- Hoeprich, Paul D.; Fischer, Nicholas O.; Blanchette, Craig
- US Patent Application 12/604362; 20100092567
Unilamellar lipid vesicles and method for their formation
patent, May 1990
- Roberts, Mary P.; Gabriel, Nancy E.
- US Patent Document 4,921,706
Method of and arrangement for producing lipid vesicles
patent, June 1984
- Gersonde, Klaus; Schal, Wilfried
- US Patent Document 4,452,747
Phospholipase A2-Resistant Liposomes
patent, April 1991
- Baumann, Wolfgang J.
- US Patent Document 5,009,956
EGF/Liposome gel composition and method
patent, July 1990
- Uster, Paul S.; Fielding, Robert M.; Martin, Francis J.
- US Patent Document 4,944,948
Liposome extrusion method
patent, May 1990
- Morano, Jacqueline K.; Martin, Francis J.; Woodle, Martin C.
- US Patent Document 4,927,637