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Title: Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems

Abstract

Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1805644
Patent Number(s):
10953085
Application Number:
15/590,918
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The United States of America, Represented by the Secretary of Agriculture (Washington, DC); University of Connecticut (Farmington, CT)
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/09/2017
Country of Publication:
United States
Language:
English

Citation Formats

Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Jr., Paul D. Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems. United States: N. p., 2021. Web.
Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., & Hoeprich, Jr., Paul D. Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems. United States.
Rieder, Aida Elizabeth, De Los Santos, Teresa B., Rodriguez, Luis Miguel, Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Jr., Paul D. Tue . "Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems". United States. https://www.osti.gov/servlets/purl/1805644.
@article{osti_1805644,
title = {Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems},
author = {Rieder, Aida Elizabeth and De Los Santos, Teresa B. and Rodriguez, Luis Miguel and Rai, Devendra and Diaz-San Segundo, Fayna C. and Hoeprich, Jr., Paul D.},
abstractNote = {Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {3}
}

Works referenced in this record:

Method of preparing a controlled release liquid pharmaceutical composition
patent, April 1977


Extrusion technique for producing unilamellar vesicles
patent, April 1991


Unilamellar lipid vesicles and method for their formation
patent, May 1990


Method of and arrangement for producing lipid vesicles
patent, June 1984


Phospholipase A2-Resistant Liposomes
patent, April 1991


EGF/Liposome gel composition and method
patent, July 1990


Liposome extrusion method
patent, May 1990