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Title: Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems

Patent ·
OSTI ID:1805644
; ; ; ; ;

Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The United States of America, Represented by the Secretary of Agriculture (Washington, DC); University of Connecticut (Farmington, CT)
Patent Number(s):
10,953,085
Application Number:
15/590,918
OSTI ID:
1805644
Resource Relation:
Patent File Date: 05/09/2017
Country of Publication:
United States
Language:
English

References (10)

Peptide patent-application August 2014
Genetically Engineered Foot and Mouth Disease Virus and Related Proteins, Polynucleotides, Compositions, Methods and Systems patent-application November 2018
Method of preparing a controlled release liquid pharmaceutical composition patent April 1977
Extrusion technique for producing unilamellar vesicles patent April 1991
Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems patent-application April 2010
Unilamellar lipid vesicles and method for their formation patent May 1990
Method of and arrangement for producing lipid vesicles patent June 1984
Phospholipase A2-Resistant Liposomes patent April 1991
EGF/Liposome gel composition and method patent July 1990
Liposome extrusion method patent May 1990

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