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Title: Mutator gene and hereditary non-polyposis colorectal cancer

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

Inventors:
 [1];  [2];  [2]
  1. Helsingfors, FI
  2. Baltimore, MD
Publication Date:
Research Org.:
ELEANOR ROOSEVELT INSTITUTE
Sponsoring Org.:
USDOE
OSTI Identifier:
983105
Patent Number(s):
7,326,778
Application Number:
08/160,295
Assignee:
The John Hopkins University (Baltimore, MD) CHO
DOE Contract Number:  
FG02-91ER61139
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States: N. p., 2008. Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Tue . "Mutator gene and hereditary non-polyposis colorectal cancer". United States. https://www.osti.gov/servlets/purl/983105.
@article{osti_983105,
title = {Mutator gene and hereditary non-polyposis colorectal cancer},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 05 00:00:00 EST 2008},
month = {Tue Feb 05 00:00:00 EST 2008}
}

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