Mutator gene and hereditary non-polyposis colorectal cancer

de la Chapelle, Albert; Vogelstein, Bert; Kinzler, Kenneth W

Title: Mutator gene and hereditary non-polyposis colorectal cancer

Patent · Tue Feb 05 00:00:00 EST 2008

OSTI ID:983105

de la Chapelle, Albert ^[1]; Vogelstein, Bert ^[2]; Kinzler, Kenneth W ^[2]

Helsingfors, FI
Baltimore, MD

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

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Research Organization:: ELEANOR ROOSEVELT INSTITUTE

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-91ER61139

Assignee:: The John Hopkins University (Baltimore, MD)

Patent Number(s):: 7,326,778

Application Number:: 08/160,295

OSTI ID:: 983105

Country of Publication:: United States

Language:: English

References (9)

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Microsatellite instability in cancer of the proximal colon Thibodeau, S.; Bren, G.; Schaid, D. Science, Vol. 260, Issue 5109 https://doi.org/10.1126/science.8484122	journal	May 1993
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair Strand, Micheline; Prolla, Tomas A.; Liskay, R. Michael Nature, Vol. 365, Issue 6443 https://doi.org/10.1038/365274a0	journal	September 1993
Hypermutability and mismatch repair deficiency in RER+ tumor cells Parsons, Ramon; Li, Guo-Min; Longley, Matthew J. Cell, Vol. 75, Issue 6 https://doi.org/10.1016/0092-8674(93)90331-J	journal	December 1993
Genetic mapping of a locus predisposing to human colorectal cancer Peltomaki, P.; Aaltonen, L.; Sistonen, P. Science, Vol. 260, Issue 5109 https://doi.org/10.1126/science.8484120	journal	May 1993
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer Fishel, Richard; Lescoe, Mary Kay; Rao, M. R. S. Cell, Vol. 75, Issue 5 https://doi.org/10.1016/0092-8674(93)90546-3	journal	December 1993
Clues to the pathogenesis of familial colorectal cancer Aaltonen, L.; Peltomaki, P.; Leach, F. Science, Vol. 260, Issue 5109 https://doi.org/10.1126/science.8484121	journal	May 1993
Slippery DNA and diseases Kunkel, Thomas A. Nature, Vol. 365, Issue 6443 https://doi.org/10.1038/365207a0	journal	September 1993
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