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Diagnostic method employing MSH2 nucleic acids

Patent ·
OSTI ID:871256
 [1];  [2];  [2]
  1. Helsingfors, FI
  2. Baltimore, MD
+ Show Author Affiliations

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

Research Organization:
Eleanor Roosevelt Institute
DOE Contract Number:
FG02-91ER61139
Assignee:
Johns Hopkins University (Baltimore, MD)
Patent Number(s):
US 5693470
OSTI ID:
871256
Country of Publication:
United States
Language:
English

References (8)

Hypermutability and mismatch repair deficiency in RER+ tumor cells journal December 1993
APC mutations occur early during colorectal tumorigenesis journal September 1992
Microsatellite instability in cancer of the proximal colon journal May 1993
Clues to the pathogenesis of familial colorectal cancer journal May 1993
Slippery DNA and diseases journal September 1993
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer journal December 1993
Genetic mapping of a locus predisposing to human colorectal cancer journal May 1993
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair journal September 1993

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/435/999/
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