Diagnostic method employing MSH2 protein
Patent
·
OSTI ID:675821
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.
- Research Organization:
- Eleanor Roosevelt Institute
- Sponsoring Organization:
- USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- FG02-91ER61139
- Assignee:
- Johns Hopkins Univ., Baltimore, MD (United States)
- Patent Number(s):
- US 5,837,443/A/
- Application Number:
- PAN: 8-457,374; CNN: Grant DOE/ERN/F139;Grant NIH CA47527;Grant NIH CA09320;Grant NIH GM26449;Grant NIH CA09243;Grant NIH CA41183;Grant NIH CA42705;Grant NIH CA57435;Grant NIH CA35494
- OSTI ID:
- 675821
- Resource Relation:
- Other Information: PBD: 17 Nov 1998
- Country of Publication:
- United States
- Language:
- English
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