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Title: Human MSH2 protein

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

Inventors:
 [1];  [2];  [2]
  1. (Helsingfors, FI)
  2. (Baltimore, MD)
Publication Date:
Research Org.:
Eleanor Roosevelt Institute
OSTI Identifier:
870772
Patent Number(s):
US 5591826
Assignee:
Johns Hopkins University (Baltimore, MD) CHO
DOE Contract Number:
FG02-91ER61139
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
human; msh2; protein; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; hereditary non-polyposis; tumor cells; replication error; mismatch repair; human msh2; germ line; msh2 protein; dna mismatch; line mutations; /530/

Citation Formats

de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Human MSH2 protein. United States: N. p., 1997. Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Human MSH2 protein. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Wed . "Human MSH2 protein". United States. doi:. https://www.osti.gov/servlets/purl/870772.
@article{osti_870772,
title = {Human MSH2 protein},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W.},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1997},
month = {Wed Jan 01 00:00:00 EST 1997}
}

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