Human MSH2 protein
Patent
·
OSTI ID:415739
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.
- Research Organization:
- Eleanor Roosevelt Institute
- DOE Contract Number:
- FG02-91ER61139
- Assignee:
- Johns Hopkins Univ., Baltimore, MD (United States)
- Patent Number(s):
- US 5,591,826/A/
- Application Number:
- PAN: 8-457,176; CNN: Grant CA47527;CA09320;GM26449;CA09243;CA41183;CA42705;CA57435;CA35494
- OSTI ID:
- 415739
- Resource Relation:
- Other Information: PBD: 7 Jan 1997
- Country of Publication:
- United States
- Language:
- English
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