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Title: Low pressure electrospray ionization system and process for effective transmission of ions

Patent ·
OSTI ID:978683
 [1];  [2];  [3];  [1]
  1. Richland, WA
  2. Kennewick, WA
  3. Wet Richland, WA
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A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,671,344
Application Number:
11/848,884
OSTI ID:
978683
Country of Publication:
United States
Language:
English

References (11)

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions journal April 2006
Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface journal September 2007
Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo journal February 2004
Charged droplet experiments journal March 1962
On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources journal March 1998
Effect of Background Gas on the Current Emitted from Taylor Cones journal May 1995
Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity journal April 2001
A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry journal October 1997
Electrohydrodynamic mass spectrometry journal January 1986
Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry journal June 2007
Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface journal September 2006

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