Low pressure electrospray ionization system and process for effective transmission of ions

Tang, Keqi; Page, Jason S; Kelly, Ryan T; Smith, Richard D

Title: Low pressure electrospray ionization system and process for effective transmission of ions

Patent · Tue May 08 00:00:00 EDT 2012

OSTI ID:1043897

Tang, Keqi ^[1]; Page, Jason S ^[2]; Kelly, Ryan T ^[3]; Smith, Richard D ^[1]

Richland, WA
Kennewick, WA
West Richland, WA

Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An "interfaceless" electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.

View Patent

Cite

Export

Save

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 8,173,960

Application Number:: 12/468,645

OSTI ID:: 1043897

Country of Publication:: United States

Language:: English

References (10)

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface Page, Jason S.; Kelly, Ryan T.; Tang, Keqi Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 9, p. 1582-1590 https://doi.org/10.1016/j.jasms.2007.05.018	journal	September 2007
Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo Romero-Sanz, I.; Fernandez de la Mora, J. Journal of Applied Physics, Vol. 95, Issue 4 https://doi.org/10.1063/1.1639947	journal	February 2004
Charged droplet experiments Hendricks, Charles D. Journal of Colloid Science, Vol. 17, Issue 3 https://doi.org/10.1016/0095-8522(62)90040-5	journal	March 1962
On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources Gamero-Castaño, M.; Aguirre-de-Carcer, I.; de Juan, L. Journal of Applied Physics, Vol. 83, Issue 5 https://doi.org/10.1063/1.367002	journal	March 1998
Effect of Background Gas on the Current Emitted from Taylor Cones Aguirre-de-Carcer, I.; de la Mora, J. Fernández Journal of Colloid and Interface Science, Vol. 171, Issue 2 https://doi.org/10.1006/jcis.1995.1210	journal	May 1995
Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity Tang, Keqi; Lin, Yuehe; Matson, Dean W. Analytical Chemistry, Vol. 73, Issue 8 https://doi.org/10.1021/ac001191r	journal	April 2001
A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry Schaffer, Scott A.; Tang, Keqi; Anderson, Gordon A. Rapid Communications in Mass Spectrometry, Vol. 11, Issue 16, p. 1813-1817 https://doi.org/10.1002/(SICI)1097-0231(19971030)11:16<1813::AID-RCM87>3.0.CO;2-D	journal	October 1997
Electrohydrodynamic mass spectrometry Cook, Kelsey D. Mass Spectrometry Reviews, Vol. 5, Issue 4 https://doi.org/10.1002/mas.1280050404	journal	January 1986
Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry Kelly, Ryan T.; Page, Jason S.; Tang, Keqi Analytical Chemistry, Vol. 79, Issue 11 https://doi.org/10.1021/ac062417e	journal	June 2007
Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface Ibrahim, Yehia; Tang, Keqi; Tolmachev, Aleksey V. Journal of the American Society for Mass Spectrometry, Vol. 17, Issue 9, p. 1299-1305 https://doi.org/10.1016/j.jasms.2006.06.005	journal	September 2006

Similar Records

Low pressure electrospray ionization system and process for effective transmission of ions

Patent · Tue Mar 02 00:00:00 EST 2010 · OSTI ID:1043897

Tang, Keqi; Page, Jason S; Kelly, Ryan T; +1 more

Subambient pressure ionization with nanoelectrospray source and interface for improved sensitivity in mass spectrometry

Journal Article · Sat Mar 01 00:00:00 EST 2008 · Analytical Chemistry, Vol. 80(5):1800-1805 · OSTI ID:1043897

Page, Jason S.; Tang, Keqi; Kelly, Ryan T.; +1 more

The Ion Funnel: Theory, Implementations and Applications.

Journal Article · Mon Mar 01 00:00:00 EST 2010 · Mass Spectrometry Reviews, 29(2):294-312 · OSTI ID:1043897

Kelly, Ryan T; Tolmachev, Aleksey V; Page, Jason S; +2 more

Related Subjects

47 OTHER INSTRUMENTATION

Title: Low pressure electrospray ionization system and process for effective transmission of ions

Citation Formats

References (10)

Similar Records

Related Subjects