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Title: Low pressure electrospray ionization system and process for effective transmission of ions

Abstract

A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.

Inventors:
 [1];  [2];  [3];  [1]
  1. Richland, WA
  2. Kennewick, WA
  3. Wet Richland, WA
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
978683
Patent Number(s):
7,671,344
Application Number:
11/848,884
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions. United States: N. p., 2010. Web.
Tang, Keqi, Page, Jason S, Kelly, Ryan T, & Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions. United States.
Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. 2010. "Low pressure electrospray ionization system and process for effective transmission of ions". United States. https://www.osti.gov/servlets/purl/978683.
@article{osti_978683,
title = {Low pressure electrospray ionization system and process for effective transmission of ions},
author = {Tang, Keqi and Page, Jason S and Kelly, Ryan T and Smith, Richard D},
abstractNote = {A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.},
doi = {},
url = {https://www.osti.gov/biblio/978683}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 02 00:00:00 EST 2010},
month = {Tue Mar 02 00:00:00 EST 2010}
}

Works referenced in this record:

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions
journal, April 2006


Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface
journal, September 2007


Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo
journal, February 2004


Charged droplet experiments
journal, March 1962


On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources
journal, March 1998


Effect of Background Gas on the Current Emitted from Taylor Cones
journal, May 1995


Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity
journal, April 2001


A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
journal, October 1997


Electrohydrodynamic mass spectrometry
journal, January 1986


Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
journal, September 2006