Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film

Journal Article · Tue Sep 01 04:00:00 EDT 2009 · Talanta, 80(1):403-406

DOI:https://doi.org/10.1016/j.talanta.2009.06.054· OSTI ID:965582

Wu, Hong; Wang, Jun; Kang, Xinhuang; Wang, Chong M; Wang, Donghai; Liu, Jun; Aksay, Ilhan A; Lin, Yuehe

The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing was described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with detection limit of 0.6 µM glucose was achieved. The biosensor also had good reproducibility, long term stability and negligible interfering signals from ascorbic acid and uric acid comparing to the response to glucose. The large surface area and good conductivity of graphene suggests that graphene is a potential candidate for sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 965582
• Report Number(s): PNNL-SA-67022; 30493
• Journal Information: Talanta, 80(1):403-406, Journal Name: Talanta, 80(1):403-406 Journal Issue: 1 Vol. 80; ISSN 0039-9140; ISSN TLNTA2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL INDICATORS
COMPOSITE MATERIALS
Environmental Molecular Sciences Laboratory
FILMS
GLUCOSE
Graphene
IMMOBILIZED CELLS
NANOSTRUCTURES
OXIDASES
PERFORMANCE
PLATINUM
Pt nanoparticle
SENSORS
biosensor