Glucose Biosensors Based on Carbon Nanotube Nanoelectrode Ensembles
- BATTELLE (PACIFIC NW LAB)
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This paper describes the development of glucose biosensors based on carbon nanotube (CNT) nanoelectrode ensembles (NEEs) for the selective detection of glucose. Glucose oxidase was covalently immobilized on CNT NEEs via carbodiimide chemistry by forming amide linkages between their amine residues and carboxylic acid groups on the CNT tips. The catalytic reduction of hydrogen peroxide liberated from the enzymatic reaction of glucose oxidase upon the glucose and oxygen on CNT NEEs leads to the selective detection of glucose. The biosensor effectively performs selective electrochemical analysis of glucose in the presence of common interferents (e.g. acetaminophen, uric and ascorbic acids), avoiding the generation of an overlapping signal from such interferents. Such an operation eliminates the need for permselective membrane barriers or artificial electron mediators, thus greatly simplifying the sensor design and fabrication.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US), Environmental Molecular Sciences Laboratory (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15006479
- Report Number(s):
- PNNL-SA-39464; 3161; TRN: US200411%%127
- Journal Information:
- Nano Letters, Vol. 4, Issue 2; Other Information: PBD: 12 Feb 2004
- Country of Publication:
- United States
- Language:
- English
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