Influenza sensor

Patent · Tue Sep 30 00:00:00 EDT 2003

OSTI ID:958675

Swanson, Basil I ^[1]; Song, Xuedong ^[1]; Unkefer, Clifford ^[1]; Schmidt, Jurgen G ^[1]

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1. Los Alamos, NM

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• Sponsoring Organization: United States Department of Energy
• DOE Contract Number: W-7405-ENG-36
• Assignee: The Regents of the University of California (Los Alamos, NM)
• Patent Number(s): 6,627,396
• Application Number: 09/699,225
• OSTI ID: 958675
• Country of Publication: United States
• Language: English