Triggered optical biosensor

Song, Xuedong; Swanson, Basil I

Triggered optical biosensor

Patent · Sun Dec 31 23:00:00 EST 2000

OSTI ID:874029

Song, Xuedong ^[1]; Swanson, Basil I ^[1]

Los Alamos, NM

An optical biosensor is provided for the detection of a multivalent target biomolecule, the biosensor including a substrate having a bilayer membrane thereon, a recognition molecule situated at the surface, the recognition molecule capable of binding with the multivalent target biomolecule, the recognition molecule further characterized as including a fluorescence label thereon and as being movable at the surface and a device for measuring a fluorescence change in response to binding between the recognition molecule and the multivalent target biomolecule.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM

DOE Contract Number:: W-7405-ENG-36

Assignee:: Regents of University of California (Los Alamos, NM)

Patent Number(s):: US 6297059

Application Number:: 09/338457

OSTI ID:: 874029

Country of Publication:: United States

Language:: English

References (14)

Use of genetically engineered lipid-tagged antibody to generate functional europium chelate-loaded liposomes Application in fluoroimmunoassay Laukkanen, Marja-Leena; Orellana, Adelina; Keinänen, Kari Journal of Immunological Methods, Vol. 185, Issue 1 https://doi.org/10.1016/0022-1759(95)00107-L	journal	September 1995
A biosensor that uses ion-channel switches Cornell, B. A.; Braach-Maksvytis, V. L. B.; King, L. G. Nature, Vol. 387, Issue 6633 https://doi.org/10.1038/42432	journal	June 1997
Optical Biosensor Based on Fluorescence Resonance Energy Transfer: Ultrasensitive and Specific Detection of Protein Toxins Song, Xuedong; Nolan, John; Swanson, Basil I. Journal of the American Chemical Society, Vol. 120, Issue 44 https://doi.org/10.1021/ja981983r	journal	November 1998
Biosynthetic lipid-tagging of antibodies Keinänen, Kari; Laukkanen, Marja-Leena FEBS Letters, Vol. 346, Issue 1 https://doi.org/10.1016/0014-5793(94)00313-0	journal	June 1994
A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor. Pagano, R. E.; Martin, O. C.; Kang, H. C. Journal of Cell Biology, Vol. 113, Issue 6 https://doi.org/10.1083/jcb.113.6.1267	journal	June 1991
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential Hope, M. J.; Bally, M. B.; Webb, G. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 812, Issue 1 https://doi.org/10.1016/0005-2736(85)90521-8	journal	January 1985
Supported Membranes: Scientific and Practical Applications Sackmann, E. Science, Vol. 271, Issue 5245 https://doi.org/10.1126/science.271.5245.43	journal	January 1996
Asymmetric incorporation of trisialoganglioside into dipalmitoylphosphatidylcholine vesicles Felgner, P. L.; Freire, E.; Barenholz, Y. Biochemistry, Vol. 20, Issue 8 https://doi.org/10.1021/bi00511a015	journal	April 1981
Direct, Ultrasensitive, and Selective Optical Detection of Protein Toxins Using Multivalent Interactions Song, Xuedong; Swanson, Basil I. Analytical Chemistry, Vol. 71, Issue 11 https://doi.org/10.1021/ac981145f	journal	June 1999
Changes in the spectral properties of a plasma membrane lipid analog during the first seconds of endocytosis in living cells Chen, C. S.; Martin, O. C.; Pagano, R. E. Biophysical Journal, Vol. 72, Issue 1 https://doi.org/10.1016/S0006-3495(97)78645-4	journal	January 1997
Protein binding to supported lipid membranes: investigation of the cholera toxin-ganglioside interaction by simultaneous impedance spectroscopy and surface plasmon resonance Terrettaz, Samuel; Stora, Thierry; Duschl, Claus Langmuir, Vol. 9, Issue 5 https://doi.org/10.1021/la00029a033	journal	May 1993
Optical Signal Transduction Triggered by Protein−Ligand Binding: Detection of Toxins Using Multivalent Binding Song, Xuedong; Nolan, John; Swanson, Basil I. Journal of the American Chemical Society, Vol. 120, Issue 19 https://doi.org/10.1021/ja980246s	journal	May 1998
Membrane receptors for bacterial toxins. Eidels, L.; Proia, R. L.; Hart, D. A. Microbiological Reviews, Vol. 47, Issue 4 https://doi.org/10.1128/MR.47.4.596-620.1983	journal	January 1983
Delineation and comparison of ganglioside-binding epitopes for the toxins of Vibrio cholerae, Escherichia coli, and Clostridium tetani: evidence for overlapping epitopes. Angstrom, J.; Teneberg, S.; Karlsson, K. A. Proceedings of the National Academy of Sciences, Vol. 91, Issue 25 https://doi.org/10.1073/pnas.91.25.11859	journal	December 1994

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/436/435/
bilayer
bilayer membrane
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fluorescence
including
label
measuring
membrane
membrane thereon
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movable
multivalent
optical
optical biosensor
provided
recognition
response
situated
substrate
surface
target
thereon
triggered

Triggered optical biosensor

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References (14)

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