X-Ray Luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ Water Soluble Nanoparticles

Journal Article · Sat Mar 15 00:00:00 EDT 2008 · Journal of Applied Physics, 103(6):Art. No. 063105

DOI:https://doi.org/10.1063/1.2890148· OSTI ID:927969

Liu, Y; Chen, Wei; Wang, Shaopeng; Joly, Alan G; Westcott, Sarah L; Woo, Boon K

Utilizing scintillation nanoparticles as agents for photodynamic therapy for cancer treatment necessitates the use of biocompatible and water soluble nanoparticles. In this article, we report the synthesis and X-ray luminescence of water soluble Ce and Tb doped LaF3 nanoparticles. The nanoparticles are conjugated with folic acid and meso-tetra (o-carboxyphenyl) porphyrin. X-ray luminescence is observed from the nanoparticles in both powder and solution samples. More importantly, singlet oxygen has been detected from the conjugated system following X-ray excitation. These preliminary observations indicate that water-soluble scintillation nanoparticles can be potentially used in photodynamic therapy for deep-tissue cancer treatment.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 927969
• Report Number(s): PNNL-SA-56544; JAPIAU; 19798; KP1504020; TRN: US200816%%927
• Journal Information: Journal of Applied Physics, 103(6):Art. No. 063105, Vol. 103, Issue 6; ISSN 0021-8979
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
60 APPLIED LIFE SCIENCES
77 NANOSCIENCE AND NANOTECHNOLOGY
NANOSTRUCTURES
THERAPY
NEOPLASMS
SYNTHESIS
CERIUM
TERBIUM
LANTHANUM FLUORIDES
X RADIATION
LUMINESCENCE
FOLIC ACID
PORPHYRINS
Environmental Molecular Sciences Laboratory