Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation
In this letter, we report the synthesis of LaF3:Tb3+-MTCP (meso-Tetra(4-carboxyphenyl) porphine) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following X-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by X-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can be potentially used to activate photodynamic therapy as a promising deep cancer treatment.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 925475
- Report Number(s):
- PNNL-SA-58245; APPLAB; 24804; KP1504020; TRN: US200809%%500
- Journal Information:
- Applied Physics Letters, 92(4):Art. No. 043901, Vol. 92, Issue 4; ISSN 0003-6951
- Country of Publication:
- United States
- Language:
- English
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