Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Weiss, Shimon; Alivisatos, Paul

Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Patent · Tue Jan 01 04:00:00 EST 2008

OSTI ID:921635

Weiss, Shimon ^[1]; Alivisatos, Paul ^[2]

Pinole, CA
Oakland, CA

A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) an affinity molecule linked to the semiconductor nanocrystal. The semiconductor nanocrystal is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Exposure of the semiconductor nanocrystal to excitation energy will excite the semiconductor nanocrystal causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

Sponsoring Organization:: United States Department of Energy

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 7,314,764

Application Number:: 11/370,656

OSTI ID:: 921635

Country of Publication:: United States

Language:: English

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