Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Weiss, Shimon; Bruchez, Jr., Marcel; Alivisatos, Paul

Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Patent · Tue Sep 05 04:00:00 EDT 2006

OSTI ID:1175902

Weiss, Shimon; Bruchez, Jr., Marcel; Alivisatos, Paul

A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 7,101,718

Application Number:: 10/918,622

OSTI ID:: 1175902

Country of Publication:: United States

Language:: English

References (21)

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