Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Weiss, Shimon; Bruchez, Jr., Marcel; Alivisatos, Paul

Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Patent · Tue Aug 09 04:00:00 EDT 2005

OSTI ID:1175456

Weiss, Shimon; Bruchez, Jr., Marcel; Alivisatos, Paul

A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

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Research Organization:: The Regents of the University of California, Oakland, CA (United States) ; Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Assignee:: The Regents of the University of California (Oakland, CA

Patent Number(s):: 6,927,069

Application Number:: 10/155,759

OSTI ID:: 1175456

Country of Publication:: United States

Language:: English

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