Effects of exposure to NO{sub 2} or SO{sub 2} on bronchopulmonary reaction induced by Candida albicans in guinea pigs

Journal Article · Fri Sep 01 04:00:00 EDT 1995 · Journal of Toxicology and Environmental Health

OSTI ID:90915

Kitabatake, Masayoshi; Yamamoto, Hidetaka; Yuan, Piao Feng ^[1]

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1. Mie Univ., Tsu (Japan); and others

The effects of NO{sub 2} or SO{sub 2} on the bronchopulmonary reactions induced by Candida albicans in guinea pigs were evaluated. Thirty-six guinea pigs (3 groups of 12 animals each) were sensitized with intraperitoneal injection of 10 mg of C. albicans, given twice. Two groups of animals were exposed to about 5 ppm of NO{sub 2} or SO{sub 2} for 4 h/d, 5 d/wk; this exposure was conducted a total of 30 times during the study. The third group served as the control and was not exposed to these pollutants. Two weeks after the second sensitization, all the animals were subjected to inhalation exposure to C. albicans. For 42 h after the antigen challenge, the respiratory rates and expiration/inspiration ratios of the animals were automatically monitored. The number of animals showing tachypnea was significantly higher in the NO{sub 2} exposure group than in the control from 15 h after antigen challenge. In the SO{sub 2} exposure group, the number of animals showing prolonged expiration or prolonged inspiration, or both, was significantly higher than that in the control group, and the symptoms were observed from approximately 15 h after antigen challenge. These findings showed that delayed-type dyspneic symptoms in guinea pigs were increased by exposure to NO{sub 2} or SO{sub 2}, although the symptoms and degree of dyspnea were different for the two gases. 29 refs., 2 figs., 2 tabs.

• OSTI ID: 90915
• Journal Information: Journal of Toxicology and Environmental Health, Journal Name: Journal of Toxicology and Environmental Health Journal Issue: 1 Vol. 45; ISSN 0098-4108; ISSN JTEHD6
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL EFFECTS
CANDIDA
GUINEA PIGS
INHALATION
INTRAPERITONEAL INJECTION
NITROGEN DIOXIDE
RESPIRATION
SULFUR DIOXIDE