Effects of sulfuric acid and nitrogen dioxide on airway responsiveness of the guinea pig

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530048· OSTI ID:6024873

Silbaugh, S A ^[1]; Mauderly, J L; Macken, C A

---

1. Lovelace Biomedical and Environmental Research, Inst., Albuquerque, NM

Hartley guinea pigs were exposed for 1 h to either NO/sub 2/ ga or H/sub 2/SO/sub 4/ aerosol and examined for changes in airway responsiveness to inhaled histamine. Concentrations ranged from 7 to 146 ppM NO/sub 2/ and 4 to 40 mg/mc H/sub 2/SO/sub 4/. One group of animals exposed to filtered air served as controls. Histamine challenges were performed on unanesthetized animals 2 h before pollutant or air exposure (baseline) and 10 min and 2 and 19 h after exposure. NO/sub 2/-exposed animals had increased histamine sensitivities 10 min after exposure, and the magnitude of the increase was directly dependent on the NO/sub 2/ concentration. Most of the NO/sub 2/-exposed animals demonstrated a dramatic return toward baseline values by 2 h after exposure; however, several animals had not returned to baseline by 19 h after exposure. Some animals exposed to H/sub 2/SO/sub 4/ developed severe labored breathing during exposure, and major increases in histamine sensitivity were observed only in those animals. These results suggest that both NO/sub 2/ and H/sub 2/SO/sub 4/ alter airway sensitivity to histamine, but apparently by different mechanisms. Changes produced by NO/sub 2/ exposures appeared primarily concentration-dependent, while changes produced by H/sub 2/SO/sub 4/ exposures appeared related to dyspnea developed during exposure.

• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6024873
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
CHALCOGENIDES
COLLOIDS
DATA
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
EVALUATED DATA
EXPERIMENTAL DATA
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROGEN COMPOUNDS
IMIDAZOLES
INFORMATION
INORGANIC ACIDS
MAMMALS
MEASURING METHODS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RESPIRATION
RODENTS
SOLS
SULFURIC ACID
VERTEBRATES