Effects of sulfuric acid aerosols on pulmonary function of guinea pigs

Journal Article · Sun Mar 01 04:00:00 EST 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109529985· OSTI ID:6459192

Silbaugh, S A; Wolff, R K; Johnson, W K; Mauderly, J L; Macken, C A

Forty-seven Hartley guinea pigs were exposed for 1 h to approximately 1 ..mu..m (mass median aerodynamic diameter) sulfuric acid aerosols at concentrations that ranged from 1.2 to 48.3 mg/m/sup 3/. Eight H/sub 2/SO/sub 4/-exposed animals exhibited marked increases in total pulmonary resistance and marked decreases in dynamic compliance. Four of these eight responsive animals died during exposure. All other H/sub 2/SO/sub 4/-exposed animals exhibited no major differences from controls and were termed nonresponsive. The proportion of responsive to nonresponsive animals increased with exposure concentration, but the magnitude of pulmonary function change was similar for all responsive animals regardless of concentration. The results suggest that the Hartley guinea pig reacts to inhaled H/sub 2/SO/sub 4/ with an essentially all-or-none airway constrictive response and that an animal's sensitivity to this response may be related to its preexposure airway caliber.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: EY-76-C-04-1013
• OSTI ID: 6459192
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 7:3-4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
GUINEA PIGS
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
LUNG CLEARANCE
LUNGS
MAMMALS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SOLS
SULFURIC ACID
VERTEBRATES
VOLUME